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Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour

In recent years, simple GO/NOGO behavioural tasks have become popular due to the relative ease with which they can be combined with technologies such as in vivo multiphoton imaging. To date, it has been assumed that behavioural performance can be captured by the average performance across a session,...

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Autores principales: Berditchevskaia, A., Cazé, R. D., Schultz, S. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895381/
https://www.ncbi.nlm.nih.gov/pubmed/27272438
http://dx.doi.org/10.1038/srep27389
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author Berditchevskaia, A.
Cazé, R. D.
Schultz, S. R.
author_facet Berditchevskaia, A.
Cazé, R. D.
Schultz, S. R.
author_sort Berditchevskaia, A.
collection PubMed
description In recent years, simple GO/NOGO behavioural tasks have become popular due to the relative ease with which they can be combined with technologies such as in vivo multiphoton imaging. To date, it has been assumed that behavioural performance can be captured by the average performance across a session, however this neglects the effect of motivation on behaviour within individual sessions. We investigated the effect of motivation on mice performing a GO/NOGO visual discrimination task. Performance within a session tended to follow a stereotypical trajectory on a Receiver Operating Characteristic (ROC) chart, beginning with an over-motivated state with many false positives, and transitioning through a more or less optimal regime to end with a low hit rate after satiation. Our observations are reproduced by a new model, the Motivated Actor-Critic, introduced here. Our results suggest that standard measures of discriminability, obtained by averaging across a session, may significantly underestimate behavioural performance.
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spelling pubmed-48953812016-06-10 Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour Berditchevskaia, A. Cazé, R. D. Schultz, S. R. Sci Rep Article In recent years, simple GO/NOGO behavioural tasks have become popular due to the relative ease with which they can be combined with technologies such as in vivo multiphoton imaging. To date, it has been assumed that behavioural performance can be captured by the average performance across a session, however this neglects the effect of motivation on behaviour within individual sessions. We investigated the effect of motivation on mice performing a GO/NOGO visual discrimination task. Performance within a session tended to follow a stereotypical trajectory on a Receiver Operating Characteristic (ROC) chart, beginning with an over-motivated state with many false positives, and transitioning through a more or less optimal regime to end with a low hit rate after satiation. Our observations are reproduced by a new model, the Motivated Actor-Critic, introduced here. Our results suggest that standard measures of discriminability, obtained by averaging across a session, may significantly underestimate behavioural performance. Nature Publishing Group 2016-06-07 /pmc/articles/PMC4895381/ /pubmed/27272438 http://dx.doi.org/10.1038/srep27389 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Berditchevskaia, A.
Cazé, R. D.
Schultz, S. R.
Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title_full Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title_fullStr Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title_full_unstemmed Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title_short Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour
title_sort performance in a go/nogo perceptual task reflects a balance between impulsive and instrumental components of behaviour
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895381/
https://www.ncbi.nlm.nih.gov/pubmed/27272438
http://dx.doi.org/10.1038/srep27389
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