CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis

Mutations in the CdGAP/ARHGAP31 gene, which encodes a GTPase-activating protein for Rac1 and Cdc42, have been reported causative in the Adams-Oliver developmental syndrome often associated with vascular defects. However, despite its abundant expression in endothelial cells, CdGAP function in the vas...

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Detalles Bibliográficos
Autores principales: Caron, Christine, DeGeer, Jonathan, Fournier, Patrick, Duquette, Philippe M., Luangrath, Vilayphone, Ishii, Hidetaka, Karimzadeh, Fereshteh, Lamarche-Vane, Nathalie, Royal, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895392/
https://www.ncbi.nlm.nih.gov/pubmed/27270835
http://dx.doi.org/10.1038/srep27485

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