USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. As HDACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. In this study, we show that ubiquitin-specific peptidase 4...

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Detalles Bibliográficos
Autores principales: Li, Z, Hao, Q, Luo, J, Xiong, J, Zhang, S, Wang, T, Bai, L, Wang, W, Chen, M, Gu, L, Lv, K, Chen, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895393/
https://www.ncbi.nlm.nih.gov/pubmed/26411366
http://dx.doi.org/10.1038/onc.2015.349

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