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Relationship between lean body mass and serum renal biomarkers in healthy dogs

BACKGROUND: Symmetric dimethylarginine (SDMA) is an accurate and precise biomarker for estimating glomerular filtration rate (GFR) in humans and cats. Serum creatinine (sCr) also correlates with GFR, but has limitations as a biomarker of renal function because nonrenal factors can influence its conc...

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Autores principales: Hall, Jean A., Yerramilli, Maha, Obare, Edward, Yerramilli, Murthy, Melendez, Lynda D., Jewell, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895404/
https://www.ncbi.nlm.nih.gov/pubmed/25913398
http://dx.doi.org/10.1111/jvim.12607
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author Hall, Jean A.
Yerramilli, Maha
Obare, Edward
Yerramilli, Murthy
Melendez, Lynda D.
Jewell, Dennis E.
author_facet Hall, Jean A.
Yerramilli, Maha
Obare, Edward
Yerramilli, Murthy
Melendez, Lynda D.
Jewell, Dennis E.
author_sort Hall, Jean A.
collection PubMed
description BACKGROUND: Symmetric dimethylarginine (SDMA) is an accurate and precise biomarker for estimating glomerular filtration rate (GFR) in humans and cats. Serum creatinine (sCr) also correlates with GFR, but has limitations as a biomarker of renal function because nonrenal factors can influence its concentration. HYPOTHESIS: Differences in lean body mass (LBM) influence sCr, but not serum SDMA concentrations. ANIMALS: Forty‐one healthy Beagles, mean age 9.9 years (range: 3.1–14.8 years), were studied over a 6 month period. METHODS: Serum biomarkers of renal function were measured prospectively at baseline, and 1, 3, and 6 months. SDMA concentrations were measured by liquid chromatography‐mass spectroscopy and sCr concentrations by enzymatic colorimetry. Body composition was determined by dual energy x‐ray absorptiometry. RESULTS: LBM (P < .001) and age (P = .006) were significant explanatory variables for sCr concentration (R (2)  = 0.38), but not SDMA concentration. Time on food was the only significant explanatory variable for SDMA concentration (R (2)  = 0.49). SDMA concentrations decreased across time (P < .001). LBM was affected by sex (males > females; P = .02). Mature adult dogs (<8 years) had greater LBM compared with geriatric dogs (≥8 years; P < .001). CONCLUSION AND CLINICAL IMPORTANCE: sCr concentrations, but not SDMA concentrations, are influenced by LBM, which limits sCr utility as a biomarker for monitoring renal function in dogs with decreased LBM. Reductions in LBM can lower sCr concentration and overestimate GFR. SDMA concentrations, but not sCr concentrations were influenced by time on food. SDMA could have clinical advantages over sCr in monitoring response to nutritional interventions.
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spelling pubmed-48954042016-06-22 Relationship between lean body mass and serum renal biomarkers in healthy dogs Hall, Jean A. Yerramilli, Maha Obare, Edward Yerramilli, Murthy Melendez, Lynda D. Jewell, Dennis E. J Vet Intern Med Standard Articles BACKGROUND: Symmetric dimethylarginine (SDMA) is an accurate and precise biomarker for estimating glomerular filtration rate (GFR) in humans and cats. Serum creatinine (sCr) also correlates with GFR, but has limitations as a biomarker of renal function because nonrenal factors can influence its concentration. HYPOTHESIS: Differences in lean body mass (LBM) influence sCr, but not serum SDMA concentrations. ANIMALS: Forty‐one healthy Beagles, mean age 9.9 years (range: 3.1–14.8 years), were studied over a 6 month period. METHODS: Serum biomarkers of renal function were measured prospectively at baseline, and 1, 3, and 6 months. SDMA concentrations were measured by liquid chromatography‐mass spectroscopy and sCr concentrations by enzymatic colorimetry. Body composition was determined by dual energy x‐ray absorptiometry. RESULTS: LBM (P < .001) and age (P = .006) were significant explanatory variables for sCr concentration (R (2)  = 0.38), but not SDMA concentration. Time on food was the only significant explanatory variable for SDMA concentration (R (2)  = 0.49). SDMA concentrations decreased across time (P < .001). LBM was affected by sex (males > females; P = .02). Mature adult dogs (<8 years) had greater LBM compared with geriatric dogs (≥8 years; P < .001). CONCLUSION AND CLINICAL IMPORTANCE: sCr concentrations, but not SDMA concentrations, are influenced by LBM, which limits sCr utility as a biomarker for monitoring renal function in dogs with decreased LBM. Reductions in LBM can lower sCr concentration and overestimate GFR. SDMA concentrations, but not sCr concentrations were influenced by time on food. SDMA could have clinical advantages over sCr in monitoring response to nutritional interventions. John Wiley and Sons Inc. 2015-04-24 2015 /pmc/articles/PMC4895404/ /pubmed/25913398 http://dx.doi.org/10.1111/jvim.12607 Text en Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Standard Articles
Hall, Jean A.
Yerramilli, Maha
Obare, Edward
Yerramilli, Murthy
Melendez, Lynda D.
Jewell, Dennis E.
Relationship between lean body mass and serum renal biomarkers in healthy dogs
title Relationship between lean body mass and serum renal biomarkers in healthy dogs
title_full Relationship between lean body mass and serum renal biomarkers in healthy dogs
title_fullStr Relationship between lean body mass and serum renal biomarkers in healthy dogs
title_full_unstemmed Relationship between lean body mass and serum renal biomarkers in healthy dogs
title_short Relationship between lean body mass and serum renal biomarkers in healthy dogs
title_sort relationship between lean body mass and serum renal biomarkers in healthy dogs
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895404/
https://www.ncbi.nlm.nih.gov/pubmed/25913398
http://dx.doi.org/10.1111/jvim.12607
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