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Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography

BACKGROUND: The study was prompted by a perceived high prevalence of myelographic complications varying in severity and type, and attributed to the contrast material or the procedure. HYPOTHESES: 1. Any adverse reaction (AAR) is associated with a change in CSF volume induced either by removal of CSF...

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Autores principales: Mullen, K.R., Furness, M.C., Johnson, A.L., Norman, T.E., Hart, K.A., Burton, A.J., Bicahlo, R.C., Ainsworth, D.M., Thompson, M.S., Scrivani, P.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895421/
https://www.ncbi.nlm.nih.gov/pubmed/25857513
http://dx.doi.org/10.1111/jvim.12590
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author Mullen, K.R.
Furness, M.C.
Johnson, A.L.
Norman, T.E.
Hart, K.A.
Burton, A.J.
Bicahlo, R.C.
Ainsworth, D.M.
Thompson, M.S.
Scrivani, P.V.
author_facet Mullen, K.R.
Furness, M.C.
Johnson, A.L.
Norman, T.E.
Hart, K.A.
Burton, A.J.
Bicahlo, R.C.
Ainsworth, D.M.
Thompson, M.S.
Scrivani, P.V.
author_sort Mullen, K.R.
collection PubMed
description BACKGROUND: The study was prompted by a perceived high prevalence of myelographic complications varying in severity and type, and attributed to the contrast material or the procedure. HYPOTHESES: 1. Any adverse reaction (AAR) is associated with a change in CSF volume induced either by removal of CSF or addition of contrast material. 2. AAR occurs more frequently in horses with higher premyelography neurologic grade. 3. Nonspecific hyperthermia is attenuated by anti‐inflammatory and osmotic agents. ANIMALS: Horses (n = 278) that underwent myelography between 2000 and 2012 at 5 institutions: A (87), B (68), C (65), D (46), and E (12). METHODS: Multi‐institutional, retrospective, observational cross‐sectional study. RESULTS: AAR were observed in 95/278 (34%) horses, were associated with longer general anesthesia time (P = .04) and higher contrast‐medium volume (P = .04); euthanasia because of AAR was performed in 5/278 (2%) horses. Adverse neurologic reactions were the most common type of complication observed occurring in 15/278 (5%) and 42/235 (18%) of horses in the intra‐ and postmyelography periods. A relationship between AAR and premyelography neurologic grade was not identified (P = .31). Nonspecific hyperthermia was observed in 25/235 (11%) horses; no relationship was observed with administration of anti‐inflammatory drugs and osmotic agents (P = .30). CONCLUSIONS AND CLINICAL IMPORTANCE: The category of AAR occurred in one‐third of the horses generally was mild and self‐limiting. These reactions were associated with increased contrast‐medium volume and longer anesthesia time; but, no specific procedural recommendations could be made because of small odds ratios (OR) of <2 for each 1 mL increase in contrast material and for each 1 minute of additional anesthesia time.
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spelling pubmed-48954212016-06-22 Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography Mullen, K.R. Furness, M.C. Johnson, A.L. Norman, T.E. Hart, K.A. Burton, A.J. Bicahlo, R.C. Ainsworth, D.M. Thompson, M.S. Scrivani, P.V. J Vet Intern Med Standard Articles BACKGROUND: The study was prompted by a perceived high prevalence of myelographic complications varying in severity and type, and attributed to the contrast material or the procedure. HYPOTHESES: 1. Any adverse reaction (AAR) is associated with a change in CSF volume induced either by removal of CSF or addition of contrast material. 2. AAR occurs more frequently in horses with higher premyelography neurologic grade. 3. Nonspecific hyperthermia is attenuated by anti‐inflammatory and osmotic agents. ANIMALS: Horses (n = 278) that underwent myelography between 2000 and 2012 at 5 institutions: A (87), B (68), C (65), D (46), and E (12). METHODS: Multi‐institutional, retrospective, observational cross‐sectional study. RESULTS: AAR were observed in 95/278 (34%) horses, were associated with longer general anesthesia time (P = .04) and higher contrast‐medium volume (P = .04); euthanasia because of AAR was performed in 5/278 (2%) horses. Adverse neurologic reactions were the most common type of complication observed occurring in 15/278 (5%) and 42/235 (18%) of horses in the intra‐ and postmyelography periods. A relationship between AAR and premyelography neurologic grade was not identified (P = .31). Nonspecific hyperthermia was observed in 25/235 (11%) horses; no relationship was observed with administration of anti‐inflammatory drugs and osmotic agents (P = .30). CONCLUSIONS AND CLINICAL IMPORTANCE: The category of AAR occurred in one‐third of the horses generally was mild and self‐limiting. These reactions were associated with increased contrast‐medium volume and longer anesthesia time; but, no specific procedural recommendations could be made because of small odds ratios (OR) of <2 for each 1 mL increase in contrast material and for each 1 minute of additional anesthesia time. John Wiley and Sons Inc. 2015-04-09 2015 /pmc/articles/PMC4895421/ /pubmed/25857513 http://dx.doi.org/10.1111/jvim.12590 Text en Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Standard Articles
Mullen, K.R.
Furness, M.C.
Johnson, A.L.
Norman, T.E.
Hart, K.A.
Burton, A.J.
Bicahlo, R.C.
Ainsworth, D.M.
Thompson, M.S.
Scrivani, P.V.
Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title_full Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title_fullStr Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title_full_unstemmed Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title_short Adverse Reactions in Horses that Underwent General Anesthesia and Cervical Myelography
title_sort adverse reactions in horses that underwent general anesthesia and cervical myelography
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895421/
https://www.ncbi.nlm.nih.gov/pubmed/25857513
http://dx.doi.org/10.1111/jvim.12590
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