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Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs

BACKGROUND: Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide. HYPOTHESIS/OBJECTIVES: Simplified strong ion equation (SSIE), using published dog‐specific valu...

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Autores principales: Cave, N.J., Koo, S.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895425/
https://www.ncbi.nlm.nih.gov/pubmed/25976610
http://dx.doi.org/10.1111/jvim.12579
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author Cave, N.J.
Koo, S.T.
author_facet Cave, N.J.
Koo, S.T.
author_sort Cave, N.J.
collection PubMed
description BACKGROUND: Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide. HYPOTHESIS/OBJECTIVES: Simplified strong ion equation (SSIE), using published dog‐specific values, would predict the measured serum pH of diseased dogs. ANIMALS: Ten dogs, hospitalized for various reasons. METHODS: Prospective study of a convenience sample of a consecutive series of dogs admitted to the Massey University Veterinary Teaching Hospital (MUVTH), from which serum biochemistry and blood gas analyses were performed at the same time. Serum pH was calculated [Formula: see text] using the SSIE, and published values for the concentration and dissociation constant for the nonvolatile weak acids (A(tot) and K (a)), and subsequently [Formula: see text] was compared with the dog's actual pH [Formula: see text]. To determine the source of discordance between [Formula: see text] and [Formula: see text] , the calculations were repeated using a series of substituted values for A(tot) and K (a). RESULTS: The [Formula: see text] did not approximate the [Formula: see text] for any dog (P = 0.499, r (2) = 0.068), and was consistently more basic. Substituted values A(tot) and K (a) did not significantly improve the accuracy (r (2) = 0.169 to <0.001). Substituting the effective SID [Formula: see text] produced a strong association between [Formula: see text] and [Formula: see text] (r (2) = 0.977). CONCLUSIONS AND CLINICAL IMPORTANCE: Using the simplified strong ion equation and the published values for A(tot) and K (a) does not appear to provide a quantitative explanation for the acid‐base status of dogs. Efficacy of substituting the effective SID in the simplified strong ion equation suggests the error lies in calculating the SID.
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spelling pubmed-48954252016-06-22 Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs Cave, N.J. Koo, S.T. J Vet Intern Med Standard Articles BACKGROUND: Electrochemical approach to the assessment of acid‐base states should provide a better mechanistic explanation of the metabolic component than methods that consider only pH and carbon dioxide. HYPOTHESIS/OBJECTIVES: Simplified strong ion equation (SSIE), using published dog‐specific values, would predict the measured serum pH of diseased dogs. ANIMALS: Ten dogs, hospitalized for various reasons. METHODS: Prospective study of a convenience sample of a consecutive series of dogs admitted to the Massey University Veterinary Teaching Hospital (MUVTH), from which serum biochemistry and blood gas analyses were performed at the same time. Serum pH was calculated [Formula: see text] using the SSIE, and published values for the concentration and dissociation constant for the nonvolatile weak acids (A(tot) and K (a)), and subsequently [Formula: see text] was compared with the dog's actual pH [Formula: see text]. To determine the source of discordance between [Formula: see text] and [Formula: see text] , the calculations were repeated using a series of substituted values for A(tot) and K (a). RESULTS: The [Formula: see text] did not approximate the [Formula: see text] for any dog (P = 0.499, r (2) = 0.068), and was consistently more basic. Substituted values A(tot) and K (a) did not significantly improve the accuracy (r (2) = 0.169 to <0.001). Substituting the effective SID [Formula: see text] produced a strong association between [Formula: see text] and [Formula: see text] (r (2) = 0.977). CONCLUSIONS AND CLINICAL IMPORTANCE: Using the simplified strong ion equation and the published values for A(tot) and K (a) does not appear to provide a quantitative explanation for the acid‐base status of dogs. Efficacy of substituting the effective SID in the simplified strong ion equation suggests the error lies in calculating the SID. John Wiley and Sons Inc. 2015-05-14 2015 /pmc/articles/PMC4895425/ /pubmed/25976610 http://dx.doi.org/10.1111/jvim.12579 Text en Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Standard Articles
Cave, N.J.
Koo, S.T.
Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title_full Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title_fullStr Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title_full_unstemmed Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title_short Quantitative Accuracy of the Simplified Strong Ion Equation to Predict Serum pH in Dogs
title_sort quantitative accuracy of the simplified strong ion equation to predict serum ph in dogs
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895425/
https://www.ncbi.nlm.nih.gov/pubmed/25976610
http://dx.doi.org/10.1111/jvim.12579
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