Cargando…

Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review

BACKGROUND: Canine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed‐restricted disorder. HYPOTHESIS/OBJECTIVES: Our objective was t...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper, J.J., Schatzberg, S.J., Vernau, K.M., Summers, B.A., Porter, B.F., Siso, S., Young, B.D., Levine, J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895549/
https://www.ncbi.nlm.nih.gov/pubmed/24428322
http://dx.doi.org/10.1111/jvim.12233
_version_ 1782435871446794240
author Cooper, J.J.
Schatzberg, S.J.
Vernau, K.M.
Summers, B.A.
Porter, B.F.
Siso, S.
Young, B.D.
Levine, J.M.
author_facet Cooper, J.J.
Schatzberg, S.J.
Vernau, K.M.
Summers, B.A.
Porter, B.F.
Siso, S.
Young, B.D.
Levine, J.M.
author_sort Cooper, J.J.
collection PubMed
description BACKGROUND: Canine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed‐restricted disorder. HYPOTHESIS/OBJECTIVES: Our objective was to describe histopathologically confirmed NME in dog breeds in which the condition has not been reported previously and to provide preliminary evidence that NME affects a wider spectrum of dog breeds than previously reported. ANIMALS: Four dogs with NME. METHODS: Archives from 3 institutions and from 1 author's (BS) collection were reviewed to identify histopathologically confirmed cases of NME in breeds in which the disease has not been reported previously. Age, sex, breed, survival from onset of clinical signs, and histopathologic findings were evaluated. RESULTS: Necrotizing meningoencephalitis was identified in 4 small dog breeds (Papillon, Shih Tzu, Coton de Tulear, and Brussels Griffon). Median age at clinical evaluation was 2.5 years. Histopathologic abnormalities included 2 or more of the following: lymphoplasmacytic or histiocytic meningoencephalitis or encephalitis, moderate‐to‐severe cerebrocortical necrosis, variable involvement of other anatomic locations within the brain (cerebellum, brainstem), and absence of detectable infectious agents. CONCLUSIONS AND CLINICAL IMPORTANCE: Until now, NME has only been described in 5 small dog breeds. We document an additional 4 small breeds previously not shown to develop NME. Our cases further illustrate that NME is not a breed‐restricted disorder and should be considered in the differential diagnosis for dogs with signalment and clinical signs consistent with inflammatory brain disease.
format Online
Article
Text
id pubmed-4895549
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-48955492016-06-22 Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review Cooper, J.J. Schatzberg, S.J. Vernau, K.M. Summers, B.A. Porter, B.F. Siso, S. Young, B.D. Levine, J.M. J Vet Intern Med Standard Articles BACKGROUND: Canine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed‐restricted disorder. HYPOTHESIS/OBJECTIVES: Our objective was to describe histopathologically confirmed NME in dog breeds in which the condition has not been reported previously and to provide preliminary evidence that NME affects a wider spectrum of dog breeds than previously reported. ANIMALS: Four dogs with NME. METHODS: Archives from 3 institutions and from 1 author's (BS) collection were reviewed to identify histopathologically confirmed cases of NME in breeds in which the disease has not been reported previously. Age, sex, breed, survival from onset of clinical signs, and histopathologic findings were evaluated. RESULTS: Necrotizing meningoencephalitis was identified in 4 small dog breeds (Papillon, Shih Tzu, Coton de Tulear, and Brussels Griffon). Median age at clinical evaluation was 2.5 years. Histopathologic abnormalities included 2 or more of the following: lymphoplasmacytic or histiocytic meningoencephalitis or encephalitis, moderate‐to‐severe cerebrocortical necrosis, variable involvement of other anatomic locations within the brain (cerebellum, brainstem), and absence of detectable infectious agents. CONCLUSIONS AND CLINICAL IMPORTANCE: Until now, NME has only been described in 5 small dog breeds. We document an additional 4 small breeds previously not shown to develop NME. Our cases further illustrate that NME is not a breed‐restricted disorder and should be considered in the differential diagnosis for dogs with signalment and clinical signs consistent with inflammatory brain disease. John Wiley and Sons Inc. 2013-11-01 2014 /pmc/articles/PMC4895549/ /pubmed/24428322 http://dx.doi.org/10.1111/jvim.12233 Text en Copyright © 2013 by the American College of Veterinary Internal Medicine
spellingShingle Standard Articles
Cooper, J.J.
Schatzberg, S.J.
Vernau, K.M.
Summers, B.A.
Porter, B.F.
Siso, S.
Young, B.D.
Levine, J.M.
Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title_full Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title_fullStr Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title_full_unstemmed Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title_short Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review
title_sort necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895549/
https://www.ncbi.nlm.nih.gov/pubmed/24428322
http://dx.doi.org/10.1111/jvim.12233
work_keys_str_mv AT cooperjj necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT schatzbergsj necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT vernaukm necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT summersba necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT porterbf necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT sisos necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT youngbd necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview
AT levinejm necrotizingmeningoencephalitisinatypicaldogbreedsacaseseriesandliteraturereview