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Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats

BACKGROUND: Direct measurement of glomerular filtration rate (GFR) is the preferred method to assess renal function in cats, but it is not widely used in the diagnosis of chronic kidney disease (CKD). In cats with CKD, symmetric dimethylarginine (SDMA) has been shown to increase and to correlate wit...

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Detalles Bibliográficos
Autores principales: Braff, J., Obare, E., Yerramilli, M., Elliott, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895615/
https://www.ncbi.nlm.nih.gov/pubmed/25272985
http://dx.doi.org/10.1111/jvim.12446
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author Braff, J.
Obare, E.
Yerramilli, M.
Elliott, J.
Yerramilli, M.
author_facet Braff, J.
Obare, E.
Yerramilli, M.
Elliott, J.
Yerramilli, M.
author_sort Braff, J.
collection PubMed
description BACKGROUND: Direct measurement of glomerular filtration rate (GFR) is the preferred method to assess renal function in cats, but it is not widely used in the diagnosis of chronic kidney disease (CKD). In cats with CKD, symmetric dimethylarginine (SDMA) has been shown to increase and to correlate with plasma creatinine concentrations. HYPOTHESIS: In cats, reduced GFR corresponds with increased serum SDMA concentration. ANIMALS: The study group consisted of ten client‐owned cats whose GFR had been measured previously. Cats ranged in age from 11.1 to 16.9 years; both azotemic and nonazotemic animals were included. METHODS: Glomerular filtration rate was determined for each cat by plasma iohexol clearance using the three sample slope‐intercept method, and serum SDMA concentration was measured by liquid chromatography‐mass spectrometry. RESULTS: A linear relationship was observed between GFR and the reciprocal of serum SDMA concentration (R (2) = 0.82, P < .001). A similar relationship was found between GFR and the reciprocal of plasma creatinine concentration (R (2) = 0.81, P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Increased serum SDMA concentrations were observed in cats with reduced renal function as determined by direct measurement of GFR. This finding indicates that SDMA could have clinical applications in the diagnosis of CKD in cats.
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spelling pubmed-48956152016-06-22 Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats Braff, J. Obare, E. Yerramilli, M. Elliott, J. Yerramilli, M. J Vet Intern Med Standard Articles BACKGROUND: Direct measurement of glomerular filtration rate (GFR) is the preferred method to assess renal function in cats, but it is not widely used in the diagnosis of chronic kidney disease (CKD). In cats with CKD, symmetric dimethylarginine (SDMA) has been shown to increase and to correlate with plasma creatinine concentrations. HYPOTHESIS: In cats, reduced GFR corresponds with increased serum SDMA concentration. ANIMALS: The study group consisted of ten client‐owned cats whose GFR had been measured previously. Cats ranged in age from 11.1 to 16.9 years; both azotemic and nonazotemic animals were included. METHODS: Glomerular filtration rate was determined for each cat by plasma iohexol clearance using the three sample slope‐intercept method, and serum SDMA concentration was measured by liquid chromatography‐mass spectrometry. RESULTS: A linear relationship was observed between GFR and the reciprocal of serum SDMA concentration (R (2) = 0.82, P < .001). A similar relationship was found between GFR and the reciprocal of plasma creatinine concentration (R (2) = 0.81, P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Increased serum SDMA concentrations were observed in cats with reduced renal function as determined by direct measurement of GFR. This finding indicates that SDMA could have clinical applications in the diagnosis of CKD in cats. John Wiley and Sons Inc. 2014-10-01 2014 /pmc/articles/PMC4895615/ /pubmed/25272985 http://dx.doi.org/10.1111/jvim.12446 Text en Copyright © 2014 by the American College of Veterinary Internal Medicine
spellingShingle Standard Articles
Braff, J.
Obare, E.
Yerramilli, M.
Elliott, J.
Yerramilli, M.
Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title_full Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title_fullStr Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title_full_unstemmed Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title_short Relationship between Serum Symmetric Dimethylarginine Concentration and Glomerular Filtration Rate in Cats
title_sort relationship between serum symmetric dimethylarginine concentration and glomerular filtration rate in cats
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895615/
https://www.ncbi.nlm.nih.gov/pubmed/25272985
http://dx.doi.org/10.1111/jvim.12446
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