Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

Compensatory mechanisms, such as relief of AKT-ErbB3-negative feedback, are known to desensitize ErbB2-dependent tumours to targeted therapy. Here we describe an adaptation mechanism leading to reactivation of the PI3K/AKT pathway during trastuzumab treatment, which occurs independently of ErbB3 re-...

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Detalles Bibliográficos
Autores principales: Tamaskovic, Rastislav, Schwill, Martin, Nagy-Davidescu, Gabriela, Jost, Christian, Schaefer, Dagmar C., Verdurmen, Wouter P. R., Schaefer, Jonas V., Honegger, Annemarie, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895728/
https://www.ncbi.nlm.nih.gov/pubmed/27255951
http://dx.doi.org/10.1038/ncomms11672

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