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Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers

INTRODUCTION: In Ayurveda Tinospora cordifolia (Willd.) Miers., has been used for its Rasayana, Deepana, Jwaranashana, Tridosha Shamaka properties. It is an immunomodulator, useful in stress, hyperlipidemia, pyrexia. T. cordifolia was evaluated for adaptogenic activity in healthy volunteers during e...

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Autores principales: Salve, Bharat A., Tripathi, Raakhi K., Petare, Anup U., Raut, Ashwinikumar A., Rege, Nirmala N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895752/
https://www.ncbi.nlm.nih.gov/pubmed/27313412
http://dx.doi.org/10.4103/0974-8520.182751
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author Salve, Bharat A.
Tripathi, Raakhi K.
Petare, Anup U.
Raut, Ashwinikumar A.
Rege, Nirmala N.
author_facet Salve, Bharat A.
Tripathi, Raakhi K.
Petare, Anup U.
Raut, Ashwinikumar A.
Rege, Nirmala N.
author_sort Salve, Bharat A.
collection PubMed
description INTRODUCTION: In Ayurveda Tinospora cordifolia (Willd.) Miers., has been used for its Rasayana, Deepana, Jwaranashana, Tridosha Shamaka properties. It is an immunomodulator, useful in stress, hyperlipidemia, pyrexia. T. cordifolia was evaluated for adaptogenic activity in healthy volunteers during exercise. AIMS: The primary objective of this study was to evaluate the effect of T. cordifolia on physical performance, and secondary objectives were to evaluate muscle power, maximal oxygen consumption, and sympathetic activity in comparison with placebo when subjected to physical stress. MATERIALS AND METHODS: A total of thirty participants were randomly assigned into three groups (n = 10 each) namely placebo, TC 150 and TC 300. Placebo group received maize starch capsule, TC 150 and TC 300 received 150 mg and 300 mg, respectively of T. cordifolia aqueous extract in capsule form once daily in the morning for 28 days. The assessment was performed at baseline visit, day 14 and 28. Physical stressors were cycle ergometer exercise, Jammer's hand-held dynamometer, and cold pressor tests. Physical performance evaluated was maximum distance and speed, oxygen consumption (VO(2) max), and hand grip strength. Cardiovascular response was assessed by multiple heart rate (HR) and blood pressure (BP) measurements during each test. RESULTS: On day 28, TC 150 mg group showed a significant increase in mean maximum speed compared to placebo. On day 14 and 28, TC 300 mg group showed a significant decrease in mean systolic BP (SBP) and HR on fixed workload exercise compared to placebo. There was significant increasing dose effect of both TC groups on SBP on day 14 and 28 and on HR on day 28 only. On day 14 and 28, TC 300 mg showed a significant decrease in mean HR on the cold pressor test, compared to placebo. CONCLUSION: T. cordifolia improved physical performance and suppressed over activation of the sympathetic nervous system showing its adaptogenic property.
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spelling pubmed-48957522016-06-16 Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers Salve, Bharat A. Tripathi, Raakhi K. Petare, Anup U. Raut, Ashwinikumar A. Rege, Nirmala N. Ayu Clinical Research INTRODUCTION: In Ayurveda Tinospora cordifolia (Willd.) Miers., has been used for its Rasayana, Deepana, Jwaranashana, Tridosha Shamaka properties. It is an immunomodulator, useful in stress, hyperlipidemia, pyrexia. T. cordifolia was evaluated for adaptogenic activity in healthy volunteers during exercise. AIMS: The primary objective of this study was to evaluate the effect of T. cordifolia on physical performance, and secondary objectives were to evaluate muscle power, maximal oxygen consumption, and sympathetic activity in comparison with placebo when subjected to physical stress. MATERIALS AND METHODS: A total of thirty participants were randomly assigned into three groups (n = 10 each) namely placebo, TC 150 and TC 300. Placebo group received maize starch capsule, TC 150 and TC 300 received 150 mg and 300 mg, respectively of T. cordifolia aqueous extract in capsule form once daily in the morning for 28 days. The assessment was performed at baseline visit, day 14 and 28. Physical stressors were cycle ergometer exercise, Jammer's hand-held dynamometer, and cold pressor tests. Physical performance evaluated was maximum distance and speed, oxygen consumption (VO(2) max), and hand grip strength. Cardiovascular response was assessed by multiple heart rate (HR) and blood pressure (BP) measurements during each test. RESULTS: On day 28, TC 150 mg group showed a significant increase in mean maximum speed compared to placebo. On day 14 and 28, TC 300 mg group showed a significant decrease in mean systolic BP (SBP) and HR on fixed workload exercise compared to placebo. There was significant increasing dose effect of both TC groups on SBP on day 14 and 28 and on HR on day 28 only. On day 14 and 28, TC 300 mg showed a significant decrease in mean HR on the cold pressor test, compared to placebo. CONCLUSION: T. cordifolia improved physical performance and suppressed over activation of the sympathetic nervous system showing its adaptogenic property. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4895752/ /pubmed/27313412 http://dx.doi.org/10.4103/0974-8520.182751 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Clinical Research
Salve, Bharat A.
Tripathi, Raakhi K.
Petare, Anup U.
Raut, Ashwinikumar A.
Rege, Nirmala N.
Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title_full Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title_fullStr Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title_full_unstemmed Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title_short Effect of Tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
title_sort effect of tinospora cordifolia on physical and cardiovascular performance induced by physical stress in healthy human volunteers
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895752/
https://www.ncbi.nlm.nih.gov/pubmed/27313412
http://dx.doi.org/10.4103/0974-8520.182751
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