Cargando…

Tenascin-C drives persistence of organ fibrosis

The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc) are not known but emerging evidence implicates toll-like receptors (TLRs) in the pathogenesis of SSc. Here we show the expression, mechanism of action and pathogenic role of endogenous TLR activators in ski...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacharyya, Swati, Wang, Wenxia, Morales-Nebreda, Luisa, Feng, Gang, Wu, Minghua, Zhou, Xiaodong, Lafyatis, Robert, Lee, Jungwha, Hinchcliff, Monique, Feghali-Bostwick, Carol, Lakota, Katja, Budinger, G. R. Scott, Raparia, Kirtee, Tamaki, Zenshiro, Varga, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895803/ https://www.ncbi.nlm.nih.gov/pubmed/27256716 http://dx.doi.org/10.1038/ncomms11703

Ejemplares similares

Molecular Signatures in Skin Associated with Clinical Improvement During Mycophenolate Treatment in Systemic Sclerosis
por: Hinchcliff, Monique, et al.
Publicado: (2013)

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?
por: Lakota, Katja, et al.
Publicado: (2012)

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis
por: Bhattacharyya, Swati, et al.
Publicado: (2018)

Serum Amyloid A Is a Marker for Pulmonary Involvement in Systemic Sclerosis
por: Lakota, Katja, et al.
Publicado: (2015)

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy
por: Fang, Feng, et al.
Publicado: (2012)

Fibrosis in systemic sclerosis: common and unique pathobiology
por: Bhattacharyya, Swati, et al.
Publicado: (2012)

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis
por: Akamata, Kaname, et al.
Publicado: (2016)

Early Stage Lung Cancer Detection in Systemic Sclerosis Does Not Portend Survival Benefit: A Cross Sectional Study
por: Katzen, Jeremy B., et al.
Publicado: (2015)

Isolated orbital mass as the primary presentation of a triple-hit lymphoma transformed from a systemic follicular lymphoma
por: Zhou, Xiao Yi, et al.
Publicado: (2018)

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis
por: Mouawad, Joe E., et al.
Publicado: (2023)

382 The Role of the IL-6-IGF-II Axis in Systemic Sclerosis-Associated Lung Fibrosis
por: Adewale, Adegboyega Timothy, et al.
Publicado: (2023)

Insulin-Like Growth Factor Binding Proteins-3 and -5: Central Mediators of Fibrosis and Promising New Therapeutic Targets
por: Veraldi, Kristen L, et al.
Publicado: (2012)

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF
por: Su, Yunyun, et al.
Publicado: (2015)

The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C
Publicado: (1994)

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis
por: Wei, Jun, et al.
Publicado: (2010)

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis
por: Yasuoka, Hidekata, et al.
Publicado: (2014)

Induction of a Th17 Phenotype in Human Skin—A Mimic of Dermal Inflammatory Diseases
por: Garrett, Sara M., et al.
Publicado: (2019)

Therapeutic Challenges And Advances In The Management Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension (SSc-PAH)
por: Argula, Rahul G, et al.
Publicado: (2019)

Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2021)

A Small Case Series of Intravascular Large B-Cell Lymphoma with Unexpected Findings: Subset of Cases with Concomitant Extravascular Central Nervous System (CNS) Involvement Mimicking Primary CNS Lymphoma
por: Poropatich, Kate, et al.
Publicado: (2017)

Genetics of systemic sclerosis: recent advances
por: Ramos, Paula S., et al.
Publicado: (2015)

A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator
por: Bhattacharyya, Swati, et al.
Publicado: (2016)

Tenascin turns on the EGFR
por: Jegalian, Karin
Publicado: (2001)

The evolution of tenascins and fibronectin
por: Adams, Josephine C, et al.
Publicado: (2015)

Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures
por: Taroni, Jaclyn N., et al.
Publicado: (2015)

The heterogeneity of lung macrophages in the susceptibility to disease
por: Morales-Nebreda, Luisa, et al.
Publicado: (2015)

Invasion of Melanoma in Double Knockout Mice Lacking Tenascin‐X and Tenascin‐C
por: Matsumoto, Ken‐ichi, et al.
Publicado: (2002)

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis
por: Ghosh, Asish K, et al.
Publicado: (2013)

Human Skin Culture as an Ex Vivo Model for Assessing the Fibrotic Effects of Insulin-Like Growth Factor Binding Proteins
por: Yasuoka, Hidekata, et al.
Publicado: (2008)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2020)

Induction of tenascin in healing wounds
Publicado: (1988)

Tenascin Supports Lymphocyte Rolling
por: Clark, Rachael A., et al.
Publicado: (1997)

Advances in tenascin-C biology
por: Midwood, Kim S., et al.
Publicado: (2011)

Tenascin-C and integrins in cancer
por: Yoshida, Toshimichi, et al.
Publicado: (2015)

Transcriptional regulation of tenascin genes
por: Chiovaro, Francesca, et al.
Publicado: (2015)

Immunosuppression via Tenascin-C
por: Bellone, Matteo, et al.
Publicado: (2015)

Tenascin-X and the pick of destiny
por: Short, Ben
Publicado: (2014)

Tenascin C in Lung Diseases
por: Donovan, Chantal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fk1lminbbi12v1irj0orvvt9t8