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A two-neuron system for adaptive goal-directed decision-making in Lymnaea
During goal-directed decision-making, animals must integrate information from the external environment and their internal state to maximize resource localization while minimizing energy expenditure. How this complex problem is solved by the nervous system remains poorly understood. Here, using a com...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895806/ https://www.ncbi.nlm.nih.gov/pubmed/27257106 http://dx.doi.org/10.1038/ncomms11793 |
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author | Crossley, Michael Staras, Kevin Kemenes, György |
author_facet | Crossley, Michael Staras, Kevin Kemenes, György |
author_sort | Crossley, Michael |
collection | PubMed |
description | During goal-directed decision-making, animals must integrate information from the external environment and their internal state to maximize resource localization while minimizing energy expenditure. How this complex problem is solved by the nervous system remains poorly understood. Here, using a combined behavioural and neurophysiological approach, we demonstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-searching behaviour, using a core system consisting of just two neuron types. The first reports the presence of food and the second encodes motivational state acting as a gain controller for adaptive behaviour in the absence of food. Using an in vitro analogue of the decision-making process, we show that the system employs an energy management strategy, switching between a low- and high-use mode depending on the outcome of the decision. Our study reveals a parsimonious mechanism that drives a complex decision-making process via regulation of levels of tonic inhibition and phasic excitation. |
format | Online Article Text |
id | pubmed-4895806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48958062016-08-18 A two-neuron system for adaptive goal-directed decision-making in Lymnaea Crossley, Michael Staras, Kevin Kemenes, György Nat Commun Article During goal-directed decision-making, animals must integrate information from the external environment and their internal state to maximize resource localization while minimizing energy expenditure. How this complex problem is solved by the nervous system remains poorly understood. Here, using a combined behavioural and neurophysiological approach, we demonstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-searching behaviour, using a core system consisting of just two neuron types. The first reports the presence of food and the second encodes motivational state acting as a gain controller for adaptive behaviour in the absence of food. Using an in vitro analogue of the decision-making process, we show that the system employs an energy management strategy, switching between a low- and high-use mode depending on the outcome of the decision. Our study reveals a parsimonious mechanism that drives a complex decision-making process via regulation of levels of tonic inhibition and phasic excitation. Nature Publishing Group 2016-06-03 /pmc/articles/PMC4895806/ /pubmed/27257106 http://dx.doi.org/10.1038/ncomms11793 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Crossley, Michael Staras, Kevin Kemenes, György A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title | A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title_full | A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title_fullStr | A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title_full_unstemmed | A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title_short | A two-neuron system for adaptive goal-directed decision-making in Lymnaea |
title_sort | two-neuron system for adaptive goal-directed decision-making in lymnaea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895806/ https://www.ncbi.nlm.nih.gov/pubmed/27257106 http://dx.doi.org/10.1038/ncomms11793 |
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