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Biometry and visual function of a healthy cohort in Leipzig, Germany

BACKGROUND: Cross-sectional survey of ocular biometry and visual function in healthy eyes across the life span of a German population aged 20 to 69 years (n = 218). Subject number in percent per age category reflected the percentage within the respective age band of the population of Leipzig, German...

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Autores principales: Zocher, Maria Teresa, Rozema, Jos J., Oertel, Nicole, Dawczynski, Jens, Wiedemann, Peter, Rauscher, Franziska G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895813/
https://www.ncbi.nlm.nih.gov/pubmed/27268271
http://dx.doi.org/10.1186/s12886-016-0232-2
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author Zocher, Maria Teresa
Rozema, Jos J.
Oertel, Nicole
Dawczynski, Jens
Wiedemann, Peter
Rauscher, Franziska G.
author_facet Zocher, Maria Teresa
Rozema, Jos J.
Oertel, Nicole
Dawczynski, Jens
Wiedemann, Peter
Rauscher, Franziska G.
author_sort Zocher, Maria Teresa
collection PubMed
description BACKGROUND: Cross-sectional survey of ocular biometry and visual function in healthy eyes across the life span of a German population aged 20 to 69 years (n = 218). Subject number in percent per age category reflected the percentage within the respective age band of the population of Leipzig, Germany. METHODS: Measurements obtained: subjective and objective refraction, best-corrected visual acuity, accommodation, contrast sensitivity, topography and pachymetry with Scheimpflug camera, axial length with non-contact partial coherence interferometry, and spectral-domain optical coherence tomography of the retina. Pearson correlation coefficients with corresponding p-values were given to present interrelationships between stature, biometric and refractive parameters or their associations with age. Two-sample T-tests were used to calculate gender differences. The area under the logarithmic contrast sensitivity function (AULCSF) was calculated for the analysis of contrast sensitivity as a single figure across a range of spatial frequencies. RESULTS: The results of axial length (AL), anterior chamber depth (ACD) and anterior chamber volume (ACV) differed as a function of the age of the participants (rho (p value): AL −0.19 (0.006), ACD −0.56 (< 0.001), ACV-0.52 (< 0.001)). Longer eyes had deeper ACD (AL:ACD 0.62 (< 0.001), greater ACV (AL:ACV 0.65 (< 0.001) and steeper corneal radii (AL:R1ant; R2ant; R1post; R2post 0.40; 0.35; 0.36; 0.36 (all with (< 0.001)). Spherical equivalent was associated with age (towards hyperopia: 0.34 (< 0.001)), AL (−0.66 (< 0.001)), ACD (−0.52 (< 0.001)) and ACV (−0.46 (< 0.001)). Accommodation was found lower for older subjects (negative association with age, r = −0.82 (< 0.001)) and contrast sensitivity presented with smaller values for older ages (AULCSF −0.38, (< 0.001)), no change of retinal thickness with age. 58 % of the study cohort presented with a change of refractive correction above ±0.50 D in one or both eyes (64 % of these were habitual spectacle wearers), need for improvement was present in the young age-group and for older subjects with increasing age. CONCLUSION: Biometrical data of healthy German eyes, stratified by age, gender and refractive status, enabled cross-comparison of all parameters, providing an important reference database for future patient-based research and specific in-depth investigations of biometric data in epidemiological research. TRIAL REGISTRATION: ClinicalTrials.gov # NCT01173614 July 28, 2010
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spelling pubmed-48958132016-06-08 Biometry and visual function of a healthy cohort in Leipzig, Germany Zocher, Maria Teresa Rozema, Jos J. Oertel, Nicole Dawczynski, Jens Wiedemann, Peter Rauscher, Franziska G. BMC Ophthalmol Research Article BACKGROUND: Cross-sectional survey of ocular biometry and visual function in healthy eyes across the life span of a German population aged 20 to 69 years (n = 218). Subject number in percent per age category reflected the percentage within the respective age band of the population of Leipzig, Germany. METHODS: Measurements obtained: subjective and objective refraction, best-corrected visual acuity, accommodation, contrast sensitivity, topography and pachymetry with Scheimpflug camera, axial length with non-contact partial coherence interferometry, and spectral-domain optical coherence tomography of the retina. Pearson correlation coefficients with corresponding p-values were given to present interrelationships between stature, biometric and refractive parameters or their associations with age. Two-sample T-tests were used to calculate gender differences. The area under the logarithmic contrast sensitivity function (AULCSF) was calculated for the analysis of contrast sensitivity as a single figure across a range of spatial frequencies. RESULTS: The results of axial length (AL), anterior chamber depth (ACD) and anterior chamber volume (ACV) differed as a function of the age of the participants (rho (p value): AL −0.19 (0.006), ACD −0.56 (< 0.001), ACV-0.52 (< 0.001)). Longer eyes had deeper ACD (AL:ACD 0.62 (< 0.001), greater ACV (AL:ACV 0.65 (< 0.001) and steeper corneal radii (AL:R1ant; R2ant; R1post; R2post 0.40; 0.35; 0.36; 0.36 (all with (< 0.001)). Spherical equivalent was associated with age (towards hyperopia: 0.34 (< 0.001)), AL (−0.66 (< 0.001)), ACD (−0.52 (< 0.001)) and ACV (−0.46 (< 0.001)). Accommodation was found lower for older subjects (negative association with age, r = −0.82 (< 0.001)) and contrast sensitivity presented with smaller values for older ages (AULCSF −0.38, (< 0.001)), no change of retinal thickness with age. 58 % of the study cohort presented with a change of refractive correction above ±0.50 D in one or both eyes (64 % of these were habitual spectacle wearers), need for improvement was present in the young age-group and for older subjects with increasing age. CONCLUSION: Biometrical data of healthy German eyes, stratified by age, gender and refractive status, enabled cross-comparison of all parameters, providing an important reference database for future patient-based research and specific in-depth investigations of biometric data in epidemiological research. TRIAL REGISTRATION: ClinicalTrials.gov # NCT01173614 July 28, 2010 BioMed Central 2016-06-07 /pmc/articles/PMC4895813/ /pubmed/27268271 http://dx.doi.org/10.1186/s12886-016-0232-2 Text en © Zocher et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zocher, Maria Teresa
Rozema, Jos J.
Oertel, Nicole
Dawczynski, Jens
Wiedemann, Peter
Rauscher, Franziska G.
Biometry and visual function of a healthy cohort in Leipzig, Germany
title Biometry and visual function of a healthy cohort in Leipzig, Germany
title_full Biometry and visual function of a healthy cohort in Leipzig, Germany
title_fullStr Biometry and visual function of a healthy cohort in Leipzig, Germany
title_full_unstemmed Biometry and visual function of a healthy cohort in Leipzig, Germany
title_short Biometry and visual function of a healthy cohort in Leipzig, Germany
title_sort biometry and visual function of a healthy cohort in leipzig, germany
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895813/
https://www.ncbi.nlm.nih.gov/pubmed/27268271
http://dx.doi.org/10.1186/s12886-016-0232-2
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