A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soyb...

Descripción completa

Detalles Bibliográficos
Autores principales: Jing, Maofeng, Guo, Baodian, Li, Haiyang, Yang, Bo, Wang, Haonan, Kong, Guanghui, Zhao, Yao, Xu, Huawei, Wang, Yan, Ye, Wenwu, Dong, Suomeng, Qiao, Yongli, Tyler, Brett M., Ma, Wenbo, Wang, Yuanchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895818/
https://www.ncbi.nlm.nih.gov/pubmed/27256489
http://dx.doi.org/10.1038/ncomms11685
_version_ 1782435931035271168
author Jing, Maofeng
Guo, Baodian
Li, Haiyang
Yang, Bo
Wang, Haonan
Kong, Guanghui
Zhao, Yao
Xu, Huawei
Wang, Yan
Ye, Wenwu
Dong, Suomeng
Qiao, Yongli
Tyler, Brett M.
Ma, Wenbo
Wang, Yuanchao
author_facet Jing, Maofeng
Guo, Baodian
Li, Haiyang
Yang, Bo
Wang, Haonan
Kong, Guanghui
Zhao, Yao
Xu, Huawei
Wang, Yan
Ye, Wenwu
Dong, Suomeng
Qiao, Yongli
Tyler, Brett M.
Ma, Wenbo
Wang, Yuanchao
author_sort Jing, Maofeng
collection PubMed
description Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.
format Online
Article
Text
id pubmed-4895818
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48958182016-08-18 A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins Jing, Maofeng Guo, Baodian Li, Haiyang Yang, Bo Wang, Haonan Kong, Guanghui Zhao, Yao Xu, Huawei Wang, Yan Ye, Wenwu Dong, Suomeng Qiao, Yongli Tyler, Brett M. Ma, Wenbo Wang, Yuanchao Nat Commun Article Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes. Nature Publishing Group 2016-06-03 /pmc/articles/PMC4895818/ /pubmed/27256489 http://dx.doi.org/10.1038/ncomms11685 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Jing, Maofeng
Guo, Baodian
Li, Haiyang
Yang, Bo
Wang, Haonan
Kong, Guanghui
Zhao, Yao
Xu, Huawei
Wang, Yan
Ye, Wenwu
Dong, Suomeng
Qiao, Yongli
Tyler, Brett M.
Ma, Wenbo
Wang, Yuanchao
A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title_full A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title_fullStr A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title_full_unstemmed A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title_short A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins
title_sort phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant binding immunoglobulin proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895818/
https://www.ncbi.nlm.nih.gov/pubmed/27256489
http://dx.doi.org/10.1038/ncomms11685
work_keys_str_mv AT jingmaofeng aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT guobaodian aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT lihaiyang aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT yangbo aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wanghaonan aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT kongguanghui aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT zhaoyao aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT xuhuawei aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wangyan aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT yewenwu aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT dongsuomeng aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT qiaoyongli aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT tylerbrettm aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT mawenbo aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wangyuanchao aphytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT jingmaofeng phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT guobaodian phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT lihaiyang phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT yangbo phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wanghaonan phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT kongguanghui phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT zhaoyao phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT xuhuawei phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wangyan phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT yewenwu phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT dongsuomeng phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT qiaoyongli phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT tylerbrettm phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT mawenbo phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins
AT wangyuanchao phytophthorasojaeeffectorsuppressesendoplasmicreticulumstressmediatedimmunitybystabilizingplantbindingimmunoglobulinproteins

Ejemplares similares