Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in fam...

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Detalles Bibliográficos
Autores principales: Fingerlin, Tasha E., Zhang, Weiming, Yang, Ivana V., Ainsworth, Hannah C., Russell, Pamela H., Blumhagen, Rachel Z., Schwarz, Marvin I., Brown, Kevin K., Steele, Mark P., Loyd, James E., Cosgrove, Gregory P., Lynch, David A., Groshong, Steve, Collard, Harold R., Wolters, Paul J., Bradford, Williamson Z., Kossen, Karl, Seiwert, Scott D., du Bois, Roland M., Garcia, Christine Kim, Devine, Megan S., Gudmundsson, Gunnar, Isaksson, Helgi J., Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F., Lancaster, Lisa H., Maher, Toby M., Molyneaux, Philip L., Wells, Athol U., Moffatt, Miriam F., Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D., Make, Barry J., Regan, Elizabeth A., Walek, Dinesha S., Daniel, Jerry J., Kamatani, Yoichiro, Zelenika, Diana, Murphy, Elissa, Smith, Keith, McKean, David, Pedersen, Brent S., Talbert, Janet, Powers, Julia, Markin, Cheryl R., Beckman, Kenneth B., Lathrop, Mark, Freed, Brian, Langefeld, Carl D., Schwartz, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895966/
https://www.ncbi.nlm.nih.gov/pubmed/27266705
http://dx.doi.org/10.1186/s12863-016-0377-2

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