BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF prom...

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Autores principales: Zheleznyakova, Galina Y., Cao, Hao, Schiöth, Helgi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895990/
https://www.ncbi.nlm.nih.gov/pubmed/27267954
http://dx.doi.org/10.1186/s12993-016-0101-4
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author Zheleznyakova, Galina Y.
Cao, Hao
Schiöth, Helgi B.
author_facet Zheleznyakova, Galina Y.
Cao, Hao
Schiöth, Helgi B.
author_sort Zheleznyakova, Galina Y.
collection PubMed
description Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
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spelling pubmed-48959902016-06-08 BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis Zheleznyakova, Galina Y. Cao, Hao Schiöth, Helgi B. Behav Brain Funct Review Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders. BioMed Central 2016-06-06 /pmc/articles/PMC4895990/ /pubmed/27267954 http://dx.doi.org/10.1186/s12993-016-0101-4 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zheleznyakova, Galina Y.
Cao, Hao
Schiöth, Helgi B.
BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title_full BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title_fullStr BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title_full_unstemmed BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title_short BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
title_sort bdnf dna methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895990/
https://www.ncbi.nlm.nih.gov/pubmed/27267954
http://dx.doi.org/10.1186/s12993-016-0101-4
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