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Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol

BACKGROUND: Thyroid dysfunction is the second most common endocrine disease in females of reproductive age. There are controversial data on the adverse effect of subclinical thyroid dysfunctions on adverse feto-maternal outcomes. OBJECTIVES: The current study aimed to identify the prevalence of thyr...

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Autores principales: Nazarpour, Sima, Ramezani Tehrani, Fahimeh, Simbar, Masoumeh, Tohidi, Maryam, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895998/
https://www.ncbi.nlm.nih.gov/pubmed/27279833
http://dx.doi.org/10.5812/ijem.33477
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author Nazarpour, Sima
Ramezani Tehrani, Fahimeh
Simbar, Masoumeh
Tohidi, Maryam
Azizi, Fereidoun
author_facet Nazarpour, Sima
Ramezani Tehrani, Fahimeh
Simbar, Masoumeh
Tohidi, Maryam
Azizi, Fereidoun
author_sort Nazarpour, Sima
collection PubMed
description BACKGROUND: Thyroid dysfunction is the second most common endocrine disease in females of reproductive age. There are controversial data on the adverse effect of subclinical thyroid dysfunctions on adverse feto-maternal outcomes. OBJECTIVES: The current study aimed to identify the prevalence of thyroid dysfunction during pregnancy and to assess the effectiveness of treatment with levothyroxine on pregnancy outcomes of females with thyroid autoimmunity with or without subclinical thyroid dysfunction in Tehran, Iran. PATIENTS AND METHODS: The study encompassed two phases: 1) a population based cross sectional study using a cluster sampling method that screened first trimester pregnant females for thyroid disorders, 2) a double-blind randomized clinical trial to determine the effectiveness of levothyroxine on adverse pregnancy outcomes in females with thyroid autoimmunity with or without subclinical thyroid dysfunction. Pregnant females were assessed at their first prenatal visit for serum TSH, T4, T-uptake, TPOAb and urinary iodine following which they were classified as: 1) normal, 2) subclinical TPOAb negative and 3) subclinical/euthyroid TPOAb positive. Females in groups two and three were randomly divided into two groups: group A was treated with levothyroxine (LT4), and group B did not receive any treatment. There was a follow-up program for participants and rates of adverse pregnancy outcomes in the treated and untreated groups were measured. RESULTS: Results of the study provided reliable information regarding the prevalence of thyroid dysfunction among females in Tehran using universal thyroid screening, along with identification of the iodine status of their community. The study aimed to determine whether LT4 treatment exerts beneficial effects in females without overt thyroid dysfunction.
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spelling pubmed-48959982016-06-08 Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol Nazarpour, Sima Ramezani Tehrani, Fahimeh Simbar, Masoumeh Tohidi, Maryam Azizi, Fereidoun Int J Endocrinol Metab Methods Article BACKGROUND: Thyroid dysfunction is the second most common endocrine disease in females of reproductive age. There are controversial data on the adverse effect of subclinical thyroid dysfunctions on adverse feto-maternal outcomes. OBJECTIVES: The current study aimed to identify the prevalence of thyroid dysfunction during pregnancy and to assess the effectiveness of treatment with levothyroxine on pregnancy outcomes of females with thyroid autoimmunity with or without subclinical thyroid dysfunction in Tehran, Iran. PATIENTS AND METHODS: The study encompassed two phases: 1) a population based cross sectional study using a cluster sampling method that screened first trimester pregnant females for thyroid disorders, 2) a double-blind randomized clinical trial to determine the effectiveness of levothyroxine on adverse pregnancy outcomes in females with thyroid autoimmunity with or without subclinical thyroid dysfunction. Pregnant females were assessed at their first prenatal visit for serum TSH, T4, T-uptake, TPOAb and urinary iodine following which they were classified as: 1) normal, 2) subclinical TPOAb negative and 3) subclinical/euthyroid TPOAb positive. Females in groups two and three were randomly divided into two groups: group A was treated with levothyroxine (LT4), and group B did not receive any treatment. There was a follow-up program for participants and rates of adverse pregnancy outcomes in the treated and untreated groups were measured. RESULTS: Results of the study provided reliable information regarding the prevalence of thyroid dysfunction among females in Tehran using universal thyroid screening, along with identification of the iodine status of their community. The study aimed to determine whether LT4 treatment exerts beneficial effects in females without overt thyroid dysfunction. Kowsar 2016-01-30 /pmc/articles/PMC4895998/ /pubmed/27279833 http://dx.doi.org/10.5812/ijem.33477 Text en Copyright © 2016, Research Institute For Endocrine Sciences and Iran Endocrine Society http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Methods Article
Nazarpour, Sima
Ramezani Tehrani, Fahimeh
Simbar, Masoumeh
Tohidi, Maryam
Azizi, Fereidoun
Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title_full Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title_fullStr Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title_full_unstemmed Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title_short Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol
title_sort thyroid and pregnancy in tehran, iran: objectives and study protocol
topic Methods Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895998/
https://www.ncbi.nlm.nih.gov/pubmed/27279833
http://dx.doi.org/10.5812/ijem.33477
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