Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation

BACKGROUND: TFEB (transcription factor EB) regulates metabolic homeostasis through its activation of lysosomal biogenesis following its nuclear translocation. TFEB activity is inhibited by mTOR phosphorylation, which signals its cytoplasmic retention. To date, the temporal relationship between alter...

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Detalles Bibliográficos
Autores principales: Marin Zapata, Paula Andrea, Beese, Carsten Jörn, Jünger, Anja, Dalmasso, Giovanni, Brady, Nathan Ryan, Hamacher-Brady, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896000/
https://www.ncbi.nlm.nih.gov/pubmed/27268034
http://dx.doi.org/10.1186/s12885-016-2388-9

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