Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer

BACKGROUND: It has been shown that epidermal growth factor receptor (EGFR) mutation status is associated with 5-fluorouracil (5-FU) sensitivity in non-small-cell lung cancer (NSCLC). However, the relationship between EGFR mutation status and dihydropyrimidine dehydrogenase (DPD), a 5-FU degrading en...

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Detalles Bibliográficos
Autores principales: Tominaga, Tetsuro, Tsuchiya, Tomoshi, Mochinaga, Koji, Arai, Junichi, Yamasaki, Naoya, Matsumoto, Keitaro, Miyazaki, Takuro, Nagasaki, Toshiya, Nanashima, Atsushi, Tsukamoto, Kazuhiro, Nagayasu, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896005/
https://www.ncbi.nlm.nih.gov/pubmed/27268079
http://dx.doi.org/10.1186/s12885-016-2392-0

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