Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation

The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest. We show that telomerase activity and cardiomyocyte telomere lengt...

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Detalles Bibliográficos
Autores principales: Aix, Esther, Gutiérrez-Gutiérrez, Óscar, Sánchez-Ferrer, Carlota, Aguado, Tania, Flores, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896054/
https://www.ncbi.nlm.nih.gov/pubmed/27241915
http://dx.doi.org/10.1083/jcb.201510091

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