Tapping out a mechanical code for T cell triggering

Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emula...

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Detalles Bibliográficos
Autores principales: Dustin, Michael L., Kam, Lance C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896060/
https://www.ncbi.nlm.nih.gov/pubmed/27269063
http://dx.doi.org/10.1083/jcb.201605072
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author Dustin, Michael L.
Kam, Lance C.
author_facet Dustin, Michael L.
Kam, Lance C.
author_sort Dustin, Michael L.
collection PubMed
description Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.
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spelling pubmed-48960602016-12-06 Tapping out a mechanical code for T cell triggering Dustin, Michael L. Kam, Lance C. J Cell Biol Commentary Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation. The Rockefeller University Press 2016-06-06 /pmc/articles/PMC4896060/ /pubmed/27269063 http://dx.doi.org/10.1083/jcb.201605072 Text en © 2016 Dustin and Kam This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Dustin, Michael L.
Kam, Lance C.
Tapping out a mechanical code for T cell triggering
title Tapping out a mechanical code for T cell triggering
title_full Tapping out a mechanical code for T cell triggering
title_fullStr Tapping out a mechanical code for T cell triggering
title_full_unstemmed Tapping out a mechanical code for T cell triggering
title_short Tapping out a mechanical code for T cell triggering
title_sort tapping out a mechanical code for t cell triggering
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896060/
https://www.ncbi.nlm.nih.gov/pubmed/27269063
http://dx.doi.org/10.1083/jcb.201605072
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AT kamlancec tappingoutamechanicalcodefortcelltriggering

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