Cargando…

Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells

BACKGROUND: Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report, oral cancer is one of the most common cancers among males and females in India...

Descripción completa

Detalles Bibliográficos
Autores principales: Parvathy, Muraleedharan, Sreeja, Sreeharshan, Kumar, Rakesh, Pillai, Madhavan Radhakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896241/
https://www.ncbi.nlm.nih.gov/pubmed/27229476
http://dx.doi.org/10.1186/s12885-016-2263-8
_version_ 1782435994314735616
author Parvathy, Muraleedharan
Sreeja, Sreeharshan
Kumar, Rakesh
Pillai, Madhavan Radhakrishna
author_facet Parvathy, Muraleedharan
Sreeja, Sreeharshan
Kumar, Rakesh
Pillai, Madhavan Radhakrishna
author_sort Parvathy, Muraleedharan
collection PubMed
description BACKGROUND: Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report, oral cancer is one of the most common cancers among males and females in India. Even though significant advancements have been made in the field of oral cancer treatment modalities, the overall prognosis for the patients has not improved in the past few decades and hence, this demands a new thrust for the identification of novel therapeutic targets in oral cancer. p21 Activated Kinases (PAKs) are potential therapeutic targets that are involved in numerous physiological functions. PAKs are serine-threonine kinases and they serve as important regulators of cytoskeletal dynamics and cell motility, transcription through MAP kinase cascades, death and survival signalling, and cell-cycle progression. Although PAKs are known to play crucial roles in cancer progression, the role and clinical significance of PAKs in oral cancer remains poorly understood. RESULTS: Our results suggest that PAK1 is over-expressed in oral cancer cell lines. Stimulation of Oral Squamous Cell Carcinoma (OSCC) cells with serum growth factors leads to PAK1 re-localization and might cause a profound cytoskeletal remodelling. PAK1 was also found to be involved in the invasion, migration and cytoskeletal remodelling of OSCC cells. CONCLUSIONS: Our study revealed that PAK1 may play a crucial role in the progression of OSCC. Studying the role of PAK1 and its substrates is likely to enhance our understanding of oral carcinogenesis and potential therapeutic value of PAKs in oral cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2263-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4896241
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-48962412016-06-10 Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells Parvathy, Muraleedharan Sreeja, Sreeharshan Kumar, Rakesh Pillai, Madhavan Radhakrishna BMC Cancer Research BACKGROUND: Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report, oral cancer is one of the most common cancers among males and females in India. Even though significant advancements have been made in the field of oral cancer treatment modalities, the overall prognosis for the patients has not improved in the past few decades and hence, this demands a new thrust for the identification of novel therapeutic targets in oral cancer. p21 Activated Kinases (PAKs) are potential therapeutic targets that are involved in numerous physiological functions. PAKs are serine-threonine kinases and they serve as important regulators of cytoskeletal dynamics and cell motility, transcription through MAP kinase cascades, death and survival signalling, and cell-cycle progression. Although PAKs are known to play crucial roles in cancer progression, the role and clinical significance of PAKs in oral cancer remains poorly understood. RESULTS: Our results suggest that PAK1 is over-expressed in oral cancer cell lines. Stimulation of Oral Squamous Cell Carcinoma (OSCC) cells with serum growth factors leads to PAK1 re-localization and might cause a profound cytoskeletal remodelling. PAK1 was also found to be involved in the invasion, migration and cytoskeletal remodelling of OSCC cells. CONCLUSIONS: Our study revealed that PAK1 may play a crucial role in the progression of OSCC. Studying the role of PAK1 and its substrates is likely to enhance our understanding of oral carcinogenesis and potential therapeutic value of PAKs in oral cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2263-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-05-16 /pmc/articles/PMC4896241/ /pubmed/27229476 http://dx.doi.org/10.1186/s12885-016-2263-8 Text en © Parvathy et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Parvathy, Muraleedharan
Sreeja, Sreeharshan
Kumar, Rakesh
Pillai, Madhavan Radhakrishna
Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title_full Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title_fullStr Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title_full_unstemmed Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title_short Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
title_sort potential role of p21 activated kinase 1 (pak1) in the invasion and motility of oral cancer cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896241/
https://www.ncbi.nlm.nih.gov/pubmed/27229476
http://dx.doi.org/10.1186/s12885-016-2263-8
work_keys_str_mv AT parvathymuraleedharan potentialroleofp21activatedkinase1pak1intheinvasionandmotilityoforalcancercells
AT sreejasreeharshan potentialroleofp21activatedkinase1pak1intheinvasionandmotilityoforalcancercells
AT kumarrakesh potentialroleofp21activatedkinase1pak1intheinvasionandmotilityoforalcancercells
AT pillaimadhavanradhakrishna potentialroleofp21activatedkinase1pak1intheinvasionandmotilityoforalcancercells