Cargando…

Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network

One of the most fundamental features of the human brain is its ability to detect and attend to salient goal-relevant events in a flexible manner. The salience network (SN), anchored in the anterior insula and the dorsal anterior cingulate cortex, plays a crucial role in this process through rapid de...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Tianwen, Cai, Weidong, Ryali, Srikanth, Supekar, Kaustubh, Menon, Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896426/
https://www.ncbi.nlm.nih.gov/pubmed/27270215
http://dx.doi.org/10.1371/journal.pbio.1002469
_version_ 1782436014727364608
author Chen, Tianwen
Cai, Weidong
Ryali, Srikanth
Supekar, Kaustubh
Menon, Vinod
author_facet Chen, Tianwen
Cai, Weidong
Ryali, Srikanth
Supekar, Kaustubh
Menon, Vinod
author_sort Chen, Tianwen
collection PubMed
description One of the most fundamental features of the human brain is its ability to detect and attend to salient goal-relevant events in a flexible manner. The salience network (SN), anchored in the anterior insula and the dorsal anterior cingulate cortex, plays a crucial role in this process through rapid detection of goal-relevant events and facilitation of access to appropriate cognitive resources. Here, we leverage the subsecond resolution of large multisession fMRI datasets from the Human Connectome Project and apply novel graph-theoretical techniques to investigate the dynamic spatiotemporal organization of the SN. We show that the large-scale brain dynamics of the SN are characterized by several distinctive and robust properties. First, the SN demonstrated the highest levels of flexibility in time-varying connectivity with other brain networks, including the frontoparietal network (FPN), the cingulate–opercular network (CON), and the ventral and dorsal attention networks (VAN and DAN). Second, dynamic functional interactions of the SN were among the most spatially varied in the brain. Third, SN nodes maintained a consistently high level of network centrality over time, indicating that this network is a hub for facilitating flexible cross-network interactions. Fourth, time-varying connectivity profiles of the SN were distinct from all other prefrontal control systems. Fifth, temporal flexibility of the SN uniquely predicted individual differences in cognitive flexibility. Importantly, each of these results was also observed in a second retest dataset, demonstrating the robustness of our findings. Our study provides fundamental new insights into the distinct dynamic functional architecture of the SN and demonstrates how this network is uniquely positioned to facilitate interactions with multiple functional systems and thereby support a wide range of cognitive processes in the human brain.
format Online
Article
Text
id pubmed-4896426
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48964262016-06-16 Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network Chen, Tianwen Cai, Weidong Ryali, Srikanth Supekar, Kaustubh Menon, Vinod PLoS Biol Research Article One of the most fundamental features of the human brain is its ability to detect and attend to salient goal-relevant events in a flexible manner. The salience network (SN), anchored in the anterior insula and the dorsal anterior cingulate cortex, plays a crucial role in this process through rapid detection of goal-relevant events and facilitation of access to appropriate cognitive resources. Here, we leverage the subsecond resolution of large multisession fMRI datasets from the Human Connectome Project and apply novel graph-theoretical techniques to investigate the dynamic spatiotemporal organization of the SN. We show that the large-scale brain dynamics of the SN are characterized by several distinctive and robust properties. First, the SN demonstrated the highest levels of flexibility in time-varying connectivity with other brain networks, including the frontoparietal network (FPN), the cingulate–opercular network (CON), and the ventral and dorsal attention networks (VAN and DAN). Second, dynamic functional interactions of the SN were among the most spatially varied in the brain. Third, SN nodes maintained a consistently high level of network centrality over time, indicating that this network is a hub for facilitating flexible cross-network interactions. Fourth, time-varying connectivity profiles of the SN were distinct from all other prefrontal control systems. Fifth, temporal flexibility of the SN uniquely predicted individual differences in cognitive flexibility. Importantly, each of these results was also observed in a second retest dataset, demonstrating the robustness of our findings. Our study provides fundamental new insights into the distinct dynamic functional architecture of the SN and demonstrates how this network is uniquely positioned to facilitate interactions with multiple functional systems and thereby support a wide range of cognitive processes in the human brain. Public Library of Science 2016-06-07 /pmc/articles/PMC4896426/ /pubmed/27270215 http://dx.doi.org/10.1371/journal.pbio.1002469 Text en © 2016 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chen, Tianwen
Cai, Weidong
Ryali, Srikanth
Supekar, Kaustubh
Menon, Vinod
Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title_full Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title_fullStr Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title_full_unstemmed Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title_short Distinct Global Brain Dynamics and Spatiotemporal Organization of the Salience Network
title_sort distinct global brain dynamics and spatiotemporal organization of the salience network
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896426/
https://www.ncbi.nlm.nih.gov/pubmed/27270215
http://dx.doi.org/10.1371/journal.pbio.1002469
work_keys_str_mv AT chentianwen distinctglobalbraindynamicsandspatiotemporalorganizationofthesaliencenetwork
AT caiweidong distinctglobalbraindynamicsandspatiotemporalorganizationofthesaliencenetwork
AT ryalisrikanth distinctglobalbraindynamicsandspatiotemporalorganizationofthesaliencenetwork
AT supekarkaustubh distinctglobalbraindynamicsandspatiotemporalorganizationofthesaliencenetwork
AT menonvinod distinctglobalbraindynamicsandspatiotemporalorganizationofthesaliencenetwork