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Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study

Neuroimaging studies suggest that category-selective regions in higher-order visual cortex are topologically organized around specific anatomical landmarks: the mid-fusiform sulcus (MFS) in the ventral temporal cortex (VTC) and lateral occipital sulcus (LOS) in the lateral occipital cortex (LOC). To...

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Autores principales: Kadipasaoglu, Cihan Mehmet, Conner, Christopher Richard, Whaley, Meagan Lee, Baboyan, Vatche George, Tandon, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896492/
https://www.ncbi.nlm.nih.gov/pubmed/27272936
http://dx.doi.org/10.1371/journal.pone.0157109
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author Kadipasaoglu, Cihan Mehmet
Conner, Christopher Richard
Whaley, Meagan Lee
Baboyan, Vatche George
Tandon, Nitin
author_facet Kadipasaoglu, Cihan Mehmet
Conner, Christopher Richard
Whaley, Meagan Lee
Baboyan, Vatche George
Tandon, Nitin
author_sort Kadipasaoglu, Cihan Mehmet
collection PubMed
description Neuroimaging studies suggest that category-selective regions in higher-order visual cortex are topologically organized around specific anatomical landmarks: the mid-fusiform sulcus (MFS) in the ventral temporal cortex (VTC) and lateral occipital sulcus (LOS) in the lateral occipital cortex (LOC). To derive precise structure-function maps from direct neural signals, we collected intracranial EEG (icEEG) recordings in a large human cohort (n = 26) undergoing implantation of subdural electrodes. A surface-based approach to grouped icEEG analysis was used to overcome challenges from sparse electrode coverage within subjects and variable cortical anatomy across subjects. The topology of category-selectivity in bilateral VTC and LOC was assessed for five classes of visual stimuli—faces, animate non-face (animals/body-parts), places, tools, and words—using correlational and linear mixed effects analyses. In the LOC, selectivity for living (faces and animate non-face) and non-living (places and tools) classes was arranged in a ventral-to-dorsal axis along the LOS. In the VTC, selectivity for living and non-living stimuli was arranged in a latero-medial axis along the MFS. Written word-selectivity was reliably localized to the intersection of the left MFS and the occipito-temporal sulcus. These findings provide direct electrophysiological evidence for topological information structuring of functional representations within higher-order visual cortex.
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spelling pubmed-48964922016-06-16 Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study Kadipasaoglu, Cihan Mehmet Conner, Christopher Richard Whaley, Meagan Lee Baboyan, Vatche George Tandon, Nitin PLoS One Research Article Neuroimaging studies suggest that category-selective regions in higher-order visual cortex are topologically organized around specific anatomical landmarks: the mid-fusiform sulcus (MFS) in the ventral temporal cortex (VTC) and lateral occipital sulcus (LOS) in the lateral occipital cortex (LOC). To derive precise structure-function maps from direct neural signals, we collected intracranial EEG (icEEG) recordings in a large human cohort (n = 26) undergoing implantation of subdural electrodes. A surface-based approach to grouped icEEG analysis was used to overcome challenges from sparse electrode coverage within subjects and variable cortical anatomy across subjects. The topology of category-selectivity in bilateral VTC and LOC was assessed for five classes of visual stimuli—faces, animate non-face (animals/body-parts), places, tools, and words—using correlational and linear mixed effects analyses. In the LOC, selectivity for living (faces and animate non-face) and non-living (places and tools) classes was arranged in a ventral-to-dorsal axis along the LOS. In the VTC, selectivity for living and non-living stimuli was arranged in a latero-medial axis along the MFS. Written word-selectivity was reliably localized to the intersection of the left MFS and the occipito-temporal sulcus. These findings provide direct electrophysiological evidence for topological information structuring of functional representations within higher-order visual cortex. Public Library of Science 2016-06-07 /pmc/articles/PMC4896492/ /pubmed/27272936 http://dx.doi.org/10.1371/journal.pone.0157109 Text en © 2016 Kadipasaoglu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kadipasaoglu, Cihan Mehmet
Conner, Christopher Richard
Whaley, Meagan Lee
Baboyan, Vatche George
Tandon, Nitin
Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title_full Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title_fullStr Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title_full_unstemmed Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title_short Category-Selectivity in Human Visual Cortex Follows Cortical Topology: A Grouped icEEG Study
title_sort category-selectivity in human visual cortex follows cortical topology: a grouped iceeg study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896492/
https://www.ncbi.nlm.nih.gov/pubmed/27272936
http://dx.doi.org/10.1371/journal.pone.0157109
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