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Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice

Matrilin-1 (Matn1), a cartilage-specific peri-cellular and extracellular matrix (ECM) protein, has been hypothesized to regulate ECM interactions and transmit mechanical signals in cartilage. Since Matn1 knock-out (Matn1(-/-)) mice exhibit a normal skeleton, its function in vivo is unclear. In this...

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Detalles Bibliográficos
Autores principales:	Chen, Yupeng, Cossman, Jack, Jayasuriya, Chathuraka T., Li, Xin, Guan, Yingjie, Fonseca, Vera, Yang, Kun, Charbonneau, Cherie, Yu, Hongchuan, Kanbe, Katsuaki, Ma, Peter, Darling, Eric, Chen, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896629/ https://www.ncbi.nlm.nih.gov/pubmed/27270603 http://dx.doi.org/10.1371/journal.pone.0156676

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