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Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

Internal ribosome entry sites (IRESs) mediate cap-independent translation of viral mRNAs. Using electron cryo-microscopy of a single specimen, we present five ribosome structures formed with the Taura syndrome virus IRES and translocase eEF2•GTP bound with sordarin. The structures suggest a trajecto...

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Detalles Bibliográficos
Autores principales:	Abeyrathne, Priyanka D, Koh, Cha San, Grant, Timothy, Grigorieff, Nikolaus, Korostelev, Andrei A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896748/ https://www.ncbi.nlm.nih.gov/pubmed/27159452 http://dx.doi.org/10.7554/eLife.14874

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