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Inductive and Deductive Approaches to Acute Cell Injury
Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897055/ https://www.ncbi.nlm.nih.gov/pubmed/27437490 http://dx.doi.org/10.1155/2014/859341 |
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author | DeGracia, Donald J. Tri Anggraini, Fika Taha, Doaa Taha Metwally Huang, Zhi-Feng |
author_facet | DeGracia, Donald J. Tri Anggraini, Fika Taha, Doaa Taha Metwally Huang, Zhi-Feng |
author_sort | DeGracia, Donald J. |
collection | PubMed |
description | Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury system. Here we contrast the application of inductive and deductive models of acute cell injury. Using brain ischemia as a case study, we discuss limitations in inductive inferences, including the inability to unambiguously assign cell death causality and the lack of a systematic quantitative framework. These limitations follow from an overemphasis on qualitative molecular pathways specific to the injured system. Our recently developed nonlinear dynamical theory of cell injury provides a generic, systematic approach to cell injury in which attractor states and system parameters are used to quantitatively characterize acute injury systems. The theoretical, empirical, and therapeutic implications of shifting to a deductive framework are discussed. We illustrate how a deductive mathematical framework offers tangible advantages over qualitative inductive models for the development of therapeutics of acutely injured biological systems. |
format | Online Article Text |
id | pubmed-4897055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48970552016-07-19 Inductive and Deductive Approaches to Acute Cell Injury DeGracia, Donald J. Tri Anggraini, Fika Taha, Doaa Taha Metwally Huang, Zhi-Feng Int Sch Res Notices Review Article Many clinically relevant forms of acute injury, such as stroke, traumatic brain injury, and myocardial infarction, have resisted treatments to prevent cell death following injury. The clinical failures can be linked to the currently used inductive models based on biological specifics of the injury system. Here we contrast the application of inductive and deductive models of acute cell injury. Using brain ischemia as a case study, we discuss limitations in inductive inferences, including the inability to unambiguously assign cell death causality and the lack of a systematic quantitative framework. These limitations follow from an overemphasis on qualitative molecular pathways specific to the injured system. Our recently developed nonlinear dynamical theory of cell injury provides a generic, systematic approach to cell injury in which attractor states and system parameters are used to quantitatively characterize acute injury systems. The theoretical, empirical, and therapeutic implications of shifting to a deductive framework are discussed. We illustrate how a deductive mathematical framework offers tangible advantages over qualitative inductive models for the development of therapeutics of acutely injured biological systems. Hindawi Publishing Corporation 2014-10-13 /pmc/articles/PMC4897055/ /pubmed/27437490 http://dx.doi.org/10.1155/2014/859341 Text en Copyright © 2014 Donald J. DeGracia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article DeGracia, Donald J. Tri Anggraini, Fika Taha, Doaa Taha Metwally Huang, Zhi-Feng Inductive and Deductive Approaches to Acute Cell Injury |
title | Inductive and Deductive Approaches to Acute Cell Injury |
title_full | Inductive and Deductive Approaches to Acute Cell Injury |
title_fullStr | Inductive and Deductive Approaches to Acute Cell Injury |
title_full_unstemmed | Inductive and Deductive Approaches to Acute Cell Injury |
title_short | Inductive and Deductive Approaches to Acute Cell Injury |
title_sort | inductive and deductive approaches to acute cell injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897055/ https://www.ncbi.nlm.nih.gov/pubmed/27437490 http://dx.doi.org/10.1155/2014/859341 |
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