CCAR1 5′ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance

MicroRNAs (miRNAs) typically bind to unstructured miRNA-binding sites in target RNAs, leading to a mutual repression of expression. Here, we report that miR-1254 interacts with structured elements in cell cycle and apoptosis regulator 1 (CCAR1) 5′ untranslated region (UTR) and this interaction enhan...

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Detalles Bibliográficos
Autores principales: Li, Gaopeng, Wu, Xiaoli, Qian, Wenchang, Cai, Huayong, Sun, Xinbao, Zhang, Weijie, Tan, Sheng, Wu, Zhengsheng, Qian, Pengxu, Ding, Keshuo, Lu, Xuefei, Zhang, Xiao, Yan, Hong, Song, Haifeng, Guang, Shouhong, Wu, Qingfa, Lobie, Peter E, Shan, Ge, Zhu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897177/
https://www.ncbi.nlm.nih.gov/pubmed/27002217
http://dx.doi.org/10.1038/cr.2016.32

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