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Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea

Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Meth...

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Autores principales: Karpouzis, Anthony, Avgeridis, Paschalis, Tripsianis, Gregory, Gatzidou, Elisavet, Kourmouli, Niki, Veletza, Stavroula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897370/
https://www.ncbi.nlm.nih.gov/pubmed/27347521
http://dx.doi.org/10.1155/2015/469402
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author Karpouzis, Anthony
Avgeridis, Paschalis
Tripsianis, Gregory
Gatzidou, Elisavet
Kourmouli, Niki
Veletza, Stavroula
author_facet Karpouzis, Anthony
Avgeridis, Paschalis
Tripsianis, Gregory
Gatzidou, Elisavet
Kourmouli, Niki
Veletza, Stavroula
author_sort Karpouzis, Anthony
collection PubMed
description Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121 matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype (p = 0.006) and of the G allele (p = 0.004) in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (p = 0.052). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea (p = 0.021 and p = 0.008, resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients.
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spelling pubmed-48973702016-06-26 Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea Karpouzis, Anthony Avgeridis, Paschalis Tripsianis, Gregory Gatzidou, Elisavet Kourmouli, Niki Veletza, Stavroula Int Sch Res Notices Research Article Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121 matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype (p = 0.006) and of the G allele (p = 0.004) in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (p = 0.052). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea (p = 0.021 and p = 0.008, resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients. Hindawi Publishing Corporation 2015-09-30 /pmc/articles/PMC4897370/ /pubmed/27347521 http://dx.doi.org/10.1155/2015/469402 Text en Copyright © 2015 Anthony Karpouzis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Karpouzis, Anthony
Avgeridis, Paschalis
Tripsianis, Gregory
Gatzidou, Elisavet
Kourmouli, Niki
Veletza, Stavroula
Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title_full Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title_fullStr Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title_full_unstemmed Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title_short Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea
title_sort assessment of tachykinin receptor 3′ gene polymorphism rs3733631 in rosacea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897370/
https://www.ncbi.nlm.nih.gov/pubmed/27347521
http://dx.doi.org/10.1155/2015/469402
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