Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity

AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a series of AR-23 analogues with low amphipathicity were designed by substitution of Ala1, Ala8 and Ile17 with positi...

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Detalles Bibliográficos
Autores principales: Zhang, Shi-Kun, Song, Jin-wen, Gong, Feng, Li, Su-Bo, Chang, Hong-Yu, Xie, Hui-Min, Gao, Hong-Wei, Tan, Ying-Xia, Ji, Shou-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897634/
https://www.ncbi.nlm.nih.gov/pubmed/27271216
http://dx.doi.org/10.1038/srep27394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897634/
https://www.ncbi.nlm.nih.gov/pubmed/27271216
http://dx.doi.org/10.1038/srep27394

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