Activation of the Renin-Angiotensin System Promotes Colitis Development

The renin-angiotensin system (RAS) plays pathogenic roles in renal and cardiovascular disorders, but whether it is involved in colitis is unclear. Here we show that RenTgMK mice that overexpress active renin from the liver developed more severe colitis than wild-type controls. More than 50% RenTgMK...

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Detalles Bibliográficos
Autores principales: Shi, Yongyan, Liu, Tianjing, He, Lei, Dougherty, Urszula, Chen, Li, Adhikari, Sarbani, Alpert, Lindsay, Zhou, Guolin, Liu, Weicheng, Wang, Jiaolong, Deb, Dilip K., Hart, John, Liu, Shu Q., Kwon, John, Pekow, Joel, Rubin, David T., Zhao, Qun, Bissonnette, Marc, Li, Yan Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897651/
https://www.ncbi.nlm.nih.gov/pubmed/27271344
http://dx.doi.org/10.1038/srep27552

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