Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice

The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohyd...

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Autores principales: Bhat, Jalal Uddin, Nizami, Qudsia, Asiaf, Asia, Parray, Shabir Ahmad, Ahmad, Shiekh Tanveer, Aslam, Mohammad, Khanam, Razia, Mujeeb, Mohammad, Umar, Sadiq, Siddiqi, Ayesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897659/
https://www.ncbi.nlm.nih.gov/pubmed/27298604
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author Bhat, Jalal Uddin
Nizami, Qudsia
Asiaf, Asia
Parray, Shabir Ahmad
Ahmad, Shiekh Tanveer
Aslam, Mohammad
Khanam, Razia
Mujeeb, Mohammad
Umar, Sadiq
Siddiqi, Ayesha
author_facet Bhat, Jalal Uddin
Nizami, Qudsia
Asiaf, Asia
Parray, Shabir Ahmad
Ahmad, Shiekh Tanveer
Aslam, Mohammad
Khanam, Razia
Mujeeb, Mohammad
Umar, Sadiq
Siddiqi, Ayesha
author_sort Bhat, Jalal Uddin
collection PubMed
description The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.
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spelling pubmed-48976592016-06-13 Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice Bhat, Jalal Uddin Nizami, Qudsia Asiaf, Asia Parray, Shabir Ahmad Ahmad, Shiekh Tanveer Aslam, Mohammad Khanam, Razia Mujeeb, Mohammad Umar, Sadiq Siddiqi, Ayesha EXCLI J Original Article The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property. Leibniz Research Centre for Working Environment and Human Factors 2012-01-20 /pmc/articles/PMC4897659/ /pubmed/27298604 Text en Copyright © 2012 Bhat et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Bhat, Jalal Uddin
Nizami, Qudsia
Asiaf, Asia
Parray, Shabir Ahmad
Ahmad, Shiekh Tanveer
Aslam, Mohammad
Khanam, Razia
Mujeeb, Mohammad
Umar, Sadiq
Siddiqi, Ayesha
Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title_full Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title_fullStr Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title_full_unstemmed Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title_short Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice
title_sort anticonvulsant activity of methanolic and aqueous extracts of melissa parviflora in experimentally induced swiss albino mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897659/
https://www.ncbi.nlm.nih.gov/pubmed/27298604
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