Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells

In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genet...

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Detalles Bibliográficos
Autores principales: Kim, Jin Il, Lee, Ilseob, Park, Sehee, Bae, Joon-Yong, Yoo, Kirim, Lemey, Philippe, Park, Mee Sook, Song, Jin-Won, Kee, Sun-Ho, Song, Ki-Joon, Park, Man-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897687/
https://www.ncbi.nlm.nih.gov/pubmed/27270757
http://dx.doi.org/10.1038/srep27480
Descripción
Sumario:In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and HA is more important for viral replication than that between PB2 and HA. However, co-adaptation of PB1-PB2-HA genes appears to be affected by complete gene constellation.

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