Cargando…
Increased airway glucose increases airway bacterial load in hyperglycaemia
Diabetes is associated with increased frequency of hospitalization due to bacterial lung infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to increased bacterial loads. In critical care patients, we observed that respiratory tract bacterial colonisation is signif...
Autores principales: | Gill, Simren K., Hui, Kailyn, Farne, Hugo, Garnett, James P., Baines, Deborah L., Moore, Luke S.P., Holmes, Alison H., Filloux, Alain, Tregoning, John S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897689/ https://www.ncbi.nlm.nih.gov/pubmed/27273266 http://dx.doi.org/10.1038/srep27636 |
Ejemplares similares
-
Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose
por: Garnett, James P, et al.
Publicado: (2013) -
Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia‐induced bacterial growth
por: Patkee, Wishwanath R. A., et al.
Publicado: (2016) -
Comparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
por: Farne, Hugo, et al.
Publicado: (2018) -
Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H(+) secretion
por: Garnett, James Peter, et al.
Publicado: (2016) -
Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ‐mediated phosphorylation of occludin
por: Kalsi, Kameljit K., et al.
Publicado: (2018)