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Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenop...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897720/ https://www.ncbi.nlm.nih.gov/pubmed/27270834 http://dx.doi.org/10.1038/srep27762 |
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author | Hu, Xiang Ma, Xiaojing Pan, Xiaoping Luo, Yuqi Xu, Yiting Xiong, Qin Bao, Yuqian Jia, Weiping |
author_facet | Hu, Xiang Ma, Xiaojing Pan, Xiaoping Luo, Yuqi Xu, Yiting Xiong, Qin Bao, Yuqian Jia, Weiping |
author_sort | Hu, Xiang |
collection | PubMed |
description | Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m(2); all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels. |
format | Online Article Text |
id | pubmed-4897720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48977202016-06-10 Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels Hu, Xiang Ma, Xiaojing Pan, Xiaoping Luo, Yuqi Xu, Yiting Xiong, Qin Bao, Yuqian Jia, Weiping Sci Rep Article Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m(2); all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels. Nature Publishing Group 2016-06-08 /pmc/articles/PMC4897720/ /pubmed/27270834 http://dx.doi.org/10.1038/srep27762 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hu, Xiang Ma, Xiaojing Pan, Xiaoping Luo, Yuqi Xu, Yiting Xiong, Qin Bao, Yuqian Jia, Weiping Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title | Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title_full | Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title_fullStr | Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title_full_unstemmed | Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title_short | Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
title_sort | association of androgen with gender difference in serum adipocyte fatty acid binding protein levels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897720/ https://www.ncbi.nlm.nih.gov/pubmed/27270834 http://dx.doi.org/10.1038/srep27762 |
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