Cargando…

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenop...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Xiang, Ma, Xiaojing, Pan, Xiaoping, Luo, Yuqi, Xu, Yiting, Xiong, Qin, Bao, Yuqian, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897720/
https://www.ncbi.nlm.nih.gov/pubmed/27270834
http://dx.doi.org/10.1038/srep27762
_version_ 1782436222203854848
author Hu, Xiang
Ma, Xiaojing
Pan, Xiaoping
Luo, Yuqi
Xu, Yiting
Xiong, Qin
Bao, Yuqian
Jia, Weiping
author_facet Hu, Xiang
Ma, Xiaojing
Pan, Xiaoping
Luo, Yuqi
Xu, Yiting
Xiong, Qin
Bao, Yuqian
Jia, Weiping
author_sort Hu, Xiang
collection PubMed
description Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m(2); all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels.
format Online
Article
Text
id pubmed-4897720
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48977202016-06-10 Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels Hu, Xiang Ma, Xiaojing Pan, Xiaoping Luo, Yuqi Xu, Yiting Xiong, Qin Bao, Yuqian Jia, Weiping Sci Rep Article Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m(2); all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels. Nature Publishing Group 2016-06-08 /pmc/articles/PMC4897720/ /pubmed/27270834 http://dx.doi.org/10.1038/srep27762 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hu, Xiang
Ma, Xiaojing
Pan, Xiaoping
Luo, Yuqi
Xu, Yiting
Xiong, Qin
Bao, Yuqian
Jia, Weiping
Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title_full Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title_fullStr Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title_full_unstemmed Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title_short Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
title_sort association of androgen with gender difference in serum adipocyte fatty acid binding protein levels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897720/
https://www.ncbi.nlm.nih.gov/pubmed/27270834
http://dx.doi.org/10.1038/srep27762
work_keys_str_mv AT huxiang associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT maxiaojing associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT panxiaoping associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT luoyuqi associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT xuyiting associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT xiongqin associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT baoyuqian associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels
AT jiaweiping associationofandrogenwithgenderdifferenceinserumadipocytefattyacidbindingproteinlevels