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RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NA...

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Detalles Bibliográficos
Autores principales: Piras, S., Furfaro, A. L., Domenicotti, C., Traverso, N., Marinari, U. M., Pronzato, M. A., Nitti, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897723/
https://www.ncbi.nlm.nih.gov/pubmed/27313835
http://dx.doi.org/10.1155/2016/9348651
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author Piras, S.
Furfaro, A. L.
Domenicotti, C.
Traverso, N.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
author_facet Piras, S.
Furfaro, A. L.
Domenicotti, C.
Traverso, N.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
author_sort Piras, S.
collection PubMed
description RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.
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spelling pubmed-48977232016-06-16 RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage Piras, S. Furfaro, A. L. Domenicotti, C. Traverso, N. Marinari, U. M. Pronzato, M. A. Nitti, M. Oxid Med Cell Longev Review Article RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells. Hindawi Publishing Corporation 2016 2016-05-25 /pmc/articles/PMC4897723/ /pubmed/27313835 http://dx.doi.org/10.1155/2016/9348651 Text en Copyright © 2016 S. Piras et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Piras, S.
Furfaro, A. L.
Domenicotti, C.
Traverso, N.
Marinari, U. M.
Pronzato, M. A.
Nitti, M.
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_full RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_fullStr RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_full_unstemmed RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_short RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
title_sort rage expression and ros generation in neurons: differentiation versus damage
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897723/
https://www.ncbi.nlm.nih.gov/pubmed/27313835
http://dx.doi.org/10.1155/2016/9348651
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