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PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

Metformin, a widely implemented anti-diabetic drug, exhibits potent anticancer efficacies. Herein a polymeric construction of Metformin, PolyMetformin (PolyMet) is successfully synthesized through conjugation of linear polyethylenimine (PEI) with dicyandiamide. The delocalization of cationic charges...

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Detalles Bibliográficos
Autores principales:	Zhao, Yi, Wang, Wei, Guo, Shutao, Wang, Yuhua, Miao, Lei, Xiong, Yang, Huang, Leaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897747/ https://www.ncbi.nlm.nih.gov/pubmed/27264609 http://dx.doi.org/10.1038/ncomms11822

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