Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

The nucleolus is a potent disease biomarker and a target in cancer therapy. Ribosome biogenesis is initiated in the nucleolus where most ribosomal (r-) proteins assemble onto precursor rRNAs. Here we systematically investigate how depletion of each of the 80 human r-proteins affects nucleolar struct...

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Detalles Bibliográficos
Autores principales: Nicolas, Emilien, Parisot, Pascaline, Pinto-Monteiro, Celina, de Walque, Roxane, De Vleeschouwer, Christophe, Lafontaine, Denis L. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897761/
https://www.ncbi.nlm.nih.gov/pubmed/27265389
http://dx.doi.org/10.1038/ncomms11390

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