The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little is known about the molecular machinery that controls the homeostasis of intermediary metabolites in mitochondria. Here we show that the activation of p53 in β-cells, by genetic...

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Detalles Bibliográficos
Autores principales: Li, Xiaomu, Cheng, Kenneth K. Y., Liu, Zhuohao, Yang, Jin-Kui, Wang, Baile, Jiang, Xue, Zhou, Yawen, Hallenborg, Philip, Hoo, Ruby L. C., Lam, Karen S. L., Ikeda, Yasuhiro, Gao, Xin, Xu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897763/
https://www.ncbi.nlm.nih.gov/pubmed/27265727
http://dx.doi.org/10.1038/ncomms11740

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