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Maternal and perinatal conditions and the risk of developing celiac disease during childhood

BACKGROUND: Celiac disease (CD) is increasing worldwide, which might be due to the changing environmental and lifestyle exposures. We aimed to explore how conditions related to maternity, delivery and the neonatal period influence CD onset during childhood. METHODS: Using Sweden’s national registers...

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Autores principales: Namatovu, Fredinah, Olsson, Cecilia, Lindkvist, Marie, Myléus, Anna, Högberg, Ulf, Ivarsson, Anneli, Sandström, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897811/
https://www.ncbi.nlm.nih.gov/pubmed/27267234
http://dx.doi.org/10.1186/s12887-016-0613-y
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author Namatovu, Fredinah
Olsson, Cecilia
Lindkvist, Marie
Myléus, Anna
Högberg, Ulf
Ivarsson, Anneli
Sandström, Olof
author_facet Namatovu, Fredinah
Olsson, Cecilia
Lindkvist, Marie
Myléus, Anna
Högberg, Ulf
Ivarsson, Anneli
Sandström, Olof
author_sort Namatovu, Fredinah
collection PubMed
description BACKGROUND: Celiac disease (CD) is increasing worldwide, which might be due to the changing environmental and lifestyle exposures. We aimed to explore how conditions related to maternity, delivery and the neonatal period influence CD onset during childhood. METHODS: Using Sweden’s national registers we had access to information on 1 912 204 children born between 1991 and 2009, 6 596 of whom developed CD before 15 years of age. Logistic regression analyses were performed to determine how CD is associated with maternity, delivery and the neonatal period. RESULTS: Regardless of sex, a reduction in CD risk was observed in children born to mothers aged ≥35 years (odds ratio [OR] 0.8; 95 % confidence interval [CI] 0.7–0.9) and with high maternal income (OR 0.9; 95 % CI 0.8–0.9). Being a second-born child, however, was positively associated with CD. Among boys, elective caesarean delivery increased the risk of CD (OR 1.2; 95 % CI 1.0–1.4), while maternal overweight (OR 0.9; 95 % CI 0.8-0.9), premature rupture of the membrane (OR 0.4; 95 % CI 0.2–0.8) and low birth weight showed a negative association. Girls had an increased CD risk compared to boys and in girls the risk was increased by repeated maternal urinary tract infections (OR 1.1; 95 % CI 1.0–1.2). CONCLUSIONS: Elective caesarean delivery and repeated maternal urinary tract infections during pregnancy are associated with increased risk of CD onset during childhood, suggesting the role of dysbiosis during early life. High maternal age and high income reduced the risk of CD, which might be due to infant-feeding practices and life style.
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spelling pubmed-48978112016-06-09 Maternal and perinatal conditions and the risk of developing celiac disease during childhood Namatovu, Fredinah Olsson, Cecilia Lindkvist, Marie Myléus, Anna Högberg, Ulf Ivarsson, Anneli Sandström, Olof BMC Pediatr Research Article BACKGROUND: Celiac disease (CD) is increasing worldwide, which might be due to the changing environmental and lifestyle exposures. We aimed to explore how conditions related to maternity, delivery and the neonatal period influence CD onset during childhood. METHODS: Using Sweden’s national registers we had access to information on 1 912 204 children born between 1991 and 2009, 6 596 of whom developed CD before 15 years of age. Logistic regression analyses were performed to determine how CD is associated with maternity, delivery and the neonatal period. RESULTS: Regardless of sex, a reduction in CD risk was observed in children born to mothers aged ≥35 years (odds ratio [OR] 0.8; 95 % confidence interval [CI] 0.7–0.9) and with high maternal income (OR 0.9; 95 % CI 0.8–0.9). Being a second-born child, however, was positively associated with CD. Among boys, elective caesarean delivery increased the risk of CD (OR 1.2; 95 % CI 1.0–1.4), while maternal overweight (OR 0.9; 95 % CI 0.8-0.9), premature rupture of the membrane (OR 0.4; 95 % CI 0.2–0.8) and low birth weight showed a negative association. Girls had an increased CD risk compared to boys and in girls the risk was increased by repeated maternal urinary tract infections (OR 1.1; 95 % CI 1.0–1.2). CONCLUSIONS: Elective caesarean delivery and repeated maternal urinary tract infections during pregnancy are associated with increased risk of CD onset during childhood, suggesting the role of dysbiosis during early life. High maternal age and high income reduced the risk of CD, which might be due to infant-feeding practices and life style. BioMed Central 2016-06-08 /pmc/articles/PMC4897811/ /pubmed/27267234 http://dx.doi.org/10.1186/s12887-016-0613-y Text en © Namatovu et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Namatovu, Fredinah
Olsson, Cecilia
Lindkvist, Marie
Myléus, Anna
Högberg, Ulf
Ivarsson, Anneli
Sandström, Olof
Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title_full Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title_fullStr Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title_full_unstemmed Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title_short Maternal and perinatal conditions and the risk of developing celiac disease during childhood
title_sort maternal and perinatal conditions and the risk of developing celiac disease during childhood
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897811/
https://www.ncbi.nlm.nih.gov/pubmed/27267234
http://dx.doi.org/10.1186/s12887-016-0613-y
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