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An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men
BACKGROUND: Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can deteriorate quality of life. The purpose of this study was to observe the effi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897870/ https://www.ncbi.nlm.nih.gov/pubmed/27267961 http://dx.doi.org/10.1186/s12894-016-0144-8 |
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author | Bozzini, Giorgio Provenzano, Marco Buffi, Nicolò Seveso, Mauro Lughezzani, Giovanni Guazzoni, Giorgio Mandressi, Alberto Taverna, Gianluigi |
author_facet | Bozzini, Giorgio Provenzano, Marco Buffi, Nicolò Seveso, Mauro Lughezzani, Giovanni Guazzoni, Giorgio Mandressi, Alberto Taverna, Gianluigi |
author_sort | Bozzini, Giorgio |
collection | PubMed |
description | BACKGROUND: Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can deteriorate quality of life. The purpose of this study was to observe the efficacy and safety of beclomethasone dipropionate rectal suppositories (Topster®) in inflammations of the lower urinary tract in men. METHODS: Patients underwent diagnostic and therapeutic protocols according to current evidence-based practice. Efficacy assessments: voiding parameters, perineal pain, International Prostate Symptom Score (IPSS), digital rectal examination (DRE). Adverse events and patient compliance were recorded throughout the study. RESULTS: One hundred eighty patients were enrolled, mean age 52 ± 14.97. Most frequent diagnosis: nonbacterial prostatitis (85 %). All patients completed visits 1 and 2. All patients were treated with beclomethasone dipropionate (BDP) suppositories, 136/180 also with Serenoa repens (SR) extract. Antibiotics were rarely required. 162/180 patients presented clinically significant improvements and terminated treatment. Mean change vs. baseline in voiding frequency: −3.55 ± 2.70 n/day in patients taking only BDP and −3.68 ± 2.81 n/day in those taking both BDP and SR (P<.0001 in both groups). Uroflowmetry improved significantly; change from baseline 3.26 ± 5.35 ml/s in BDP only group and 5.61 ± 7.32 ml/s in BDP + SR group (P = 0.0002 for BDP, P<.0001 for BDP + SR). Urine stream normal in 35 % of patients at visit 1 and 57.22 % of patients at visit 2. Mean change in perineal pain, on 0–10 VAS, −0.66 ± 2.24 for BDP only group (P = 0.0699) and −1.37 ± 2.40 for BDP + SR group (P<.0001). IPSS increased at visit 2. No adverse events were reported. For all parameters, none of the comparisons between groups was found to be statistically significant. CONCLUSION: This study confirmed the drug’s good safety profile. We also observed an improvement in the main storage symptoms and clinical findings associated with lower urinary tract inflammation in patients treated with beclomethasone dipropionate suppositories. |
format | Online Article Text |
id | pubmed-4897870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48978702016-06-09 An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men Bozzini, Giorgio Provenzano, Marco Buffi, Nicolò Seveso, Mauro Lughezzani, Giovanni Guazzoni, Giorgio Mandressi, Alberto Taverna, Gianluigi BMC Urol Research Article BACKGROUND: Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can deteriorate quality of life. The purpose of this study was to observe the efficacy and safety of beclomethasone dipropionate rectal suppositories (Topster®) in inflammations of the lower urinary tract in men. METHODS: Patients underwent diagnostic and therapeutic protocols according to current evidence-based practice. Efficacy assessments: voiding parameters, perineal pain, International Prostate Symptom Score (IPSS), digital rectal examination (DRE). Adverse events and patient compliance were recorded throughout the study. RESULTS: One hundred eighty patients were enrolled, mean age 52 ± 14.97. Most frequent diagnosis: nonbacterial prostatitis (85 %). All patients completed visits 1 and 2. All patients were treated with beclomethasone dipropionate (BDP) suppositories, 136/180 also with Serenoa repens (SR) extract. Antibiotics were rarely required. 162/180 patients presented clinically significant improvements and terminated treatment. Mean change vs. baseline in voiding frequency: −3.55 ± 2.70 n/day in patients taking only BDP and −3.68 ± 2.81 n/day in those taking both BDP and SR (P<.0001 in both groups). Uroflowmetry improved significantly; change from baseline 3.26 ± 5.35 ml/s in BDP only group and 5.61 ± 7.32 ml/s in BDP + SR group (P = 0.0002 for BDP, P<.0001 for BDP + SR). Urine stream normal in 35 % of patients at visit 1 and 57.22 % of patients at visit 2. Mean change in perineal pain, on 0–10 VAS, −0.66 ± 2.24 for BDP only group (P = 0.0699) and −1.37 ± 2.40 for BDP + SR group (P<.0001). IPSS increased at visit 2. No adverse events were reported. For all parameters, none of the comparisons between groups was found to be statistically significant. CONCLUSION: This study confirmed the drug’s good safety profile. We also observed an improvement in the main storage symptoms and clinical findings associated with lower urinary tract inflammation in patients treated with beclomethasone dipropionate suppositories. BioMed Central 2016-06-08 /pmc/articles/PMC4897870/ /pubmed/27267961 http://dx.doi.org/10.1186/s12894-016-0144-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Bozzini, Giorgio Provenzano, Marco Buffi, Nicolò Seveso, Mauro Lughezzani, Giovanni Guazzoni, Giorgio Mandressi, Alberto Taverna, Gianluigi An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title | An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title_full | An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title_fullStr | An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title_full_unstemmed | An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title_short | An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
title_sort | observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897870/ https://www.ncbi.nlm.nih.gov/pubmed/27267961 http://dx.doi.org/10.1186/s12894-016-0144-8 |
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