Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG

We present the case of a 61-year-old man who underwent I-123 metaiodobenzylguanidine (MIBG) scintigraphy based on clinical suspicion of pheochromocytoma. The study was nondiagnostic secondary to diffuse muscle uptake. On review of his medications, the patient was found to be taking mirtazapine, a te...

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Detalles Bibliográficos
Autores principales: Goel, Sumina R., Ponzo, Fabio, Friedman, Kent P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898006/
https://www.ncbi.nlm.nih.gov/pubmed/27307825
http://dx.doi.org/10.2484/rcr.v4i3.306
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author Goel, Sumina R.
Ponzo, Fabio
Friedman, Kent P.
author_facet Goel, Sumina R.
Ponzo, Fabio
Friedman, Kent P.
author_sort Goel, Sumina R.
collection PubMed
description We present the case of a 61-year-old man who underwent I-123 metaiodobenzylguanidine (MIBG) scintigraphy based on clinical suspicion of pheochromocytoma. The study was nondiagnostic secondary to diffuse muscle uptake. On review of his medications, the patient was found to be taking mirtazapine, a tetracyclic antidepressant (Remeron). We hypothesize that the MIBG biodistribution was altered by mirtazapine-mediated blockade of the presynaptic alpha-2 receptor. To our knowledge, tetracyclic antidepressants have not been previously reported to cause altered biodistribution on I-123 MIBG scans.
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spelling pubmed-48980062016-06-15 Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG Goel, Sumina R. Ponzo, Fabio Friedman, Kent P. Radiol Case Rep Article We present the case of a 61-year-old man who underwent I-123 metaiodobenzylguanidine (MIBG) scintigraphy based on clinical suspicion of pheochromocytoma. The study was nondiagnostic secondary to diffuse muscle uptake. On review of his medications, the patient was found to be taking mirtazapine, a tetracyclic antidepressant (Remeron). We hypothesize that the MIBG biodistribution was altered by mirtazapine-mediated blockade of the presynaptic alpha-2 receptor. To our knowledge, tetracyclic antidepressants have not been previously reported to cause altered biodistribution on I-123 MIBG scans. Elsevier 2015-12-07 /pmc/articles/PMC4898006/ /pubmed/27307825 http://dx.doi.org/10.2484/rcr.v4i3.306 Text en © 2009 The Authors. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Goel, Sumina R.
Ponzo, Fabio
Friedman, Kent P.
Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title_full Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title_fullStr Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title_full_unstemmed Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title_short Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
title_sort tetracyclic antidepressant causing altered biodistribution of mibg
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898006/
https://www.ncbi.nlm.nih.gov/pubmed/27307825
http://dx.doi.org/10.2484/rcr.v4i3.306
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