Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii

Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and...

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Autores principales: Shrestha, Gentle Sunder, Tamang, Sushil, Paneru, Hem Raj, Shrestha, Pramesh Sunder, Keyal, Niraj, Acharya, Subhash Prasad, Marhatta, Moda Nath, Shilpakar, Sushil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898118/
https://www.ncbi.nlm.nih.gov/pubmed/27365967
http://dx.doi.org/10.4103/0976-3147.176194
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author Shrestha, Gentle Sunder
Tamang, Sushil
Paneru, Hem Raj
Shrestha, Pramesh Sunder
Keyal, Niraj
Acharya, Subhash Prasad
Marhatta, Moda Nath
Shilpakar, Sushil
author_facet Shrestha, Gentle Sunder
Tamang, Sushil
Paneru, Hem Raj
Shrestha, Pramesh Sunder
Keyal, Niraj
Acharya, Subhash Prasad
Marhatta, Moda Nath
Shilpakar, Sushil
author_sort Shrestha, Gentle Sunder
collection PubMed
description Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and intraventricular colistin together with intravenous tigecycline. The patient developed nephrotoxicity and poor neurological outcome despite microbiological cure. Careful implementation of bundle of measures to minimize EVD-associated ventriculitis is valuable.
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spelling pubmed-48981182016-07-01 Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii Shrestha, Gentle Sunder Tamang, Sushil Paneru, Hem Raj Shrestha, Pramesh Sunder Keyal, Niraj Acharya, Subhash Prasad Marhatta, Moda Nath Shilpakar, Sushil J Neurosci Rural Pract Case Report Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and intraventricular colistin together with intravenous tigecycline. The patient developed nephrotoxicity and poor neurological outcome despite microbiological cure. Careful implementation of bundle of measures to minimize EVD-associated ventriculitis is valuable. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4898118/ /pubmed/27365967 http://dx.doi.org/10.4103/0976-3147.176194 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Shrestha, Gentle Sunder
Tamang, Sushil
Paneru, Hem Raj
Shrestha, Pramesh Sunder
Keyal, Niraj
Acharya, Subhash Prasad
Marhatta, Moda Nath
Shilpakar, Sushil
Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title_full Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title_fullStr Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title_full_unstemmed Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title_short Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii
title_sort colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant acinetobacter baumannii
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898118/
https://www.ncbi.nlm.nih.gov/pubmed/27365967
http://dx.doi.org/10.4103/0976-3147.176194
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