Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

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Introduction: Transthyretin amyloidosis (ATTR amyloidosis) is caused by the misfolding and deposition of the transthyretin (TTR) protein and results in progressive multi-organ dysfunction. TTR epitopes exposed by dissociation and misfolding are targets for immunotherapeutic antibodies. We developed...

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Detalles Bibliográficos
Autores principales: Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Flanagan, Ken, Zago, Wagner, Kinney, Gene G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898150/
https://www.ncbi.nlm.nih.gov/pubmed/26981744
http://dx.doi.org/10.3109/13506129.2016.1148025
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