The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction

The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal gr...

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Autores principales: Finn-Sell, Sarah L., Renshall, Lewis J., Cowley, Elizabeth J., Dilworth, Mark R., Wareing, Mark, Greenwood, Susan L., Sibley, Colin P., Cottrell, Elizabeth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898207/
https://www.ncbi.nlm.nih.gov/pubmed/27238710
http://dx.doi.org/10.1016/j.placenta.2016.04.003
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author Finn-Sell, Sarah L.
Renshall, Lewis J.
Cowley, Elizabeth J.
Dilworth, Mark R.
Wareing, Mark
Greenwood, Susan L.
Sibley, Colin P.
Cottrell, Elizabeth C.
author_facet Finn-Sell, Sarah L.
Renshall, Lewis J.
Cowley, Elizabeth J.
Dilworth, Mark R.
Wareing, Mark
Greenwood, Susan L.
Sibley, Colin P.
Cottrell, Elizabeth C.
author_sort Finn-Sell, Sarah L.
collection PubMed
description The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(−/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(−/−) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR.
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spelling pubmed-48982072016-06-20 The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction Finn-Sell, Sarah L. Renshall, Lewis J. Cowley, Elizabeth J. Dilworth, Mark R. Wareing, Mark Greenwood, Susan L. Sibley, Colin P. Cottrell, Elizabeth C. Placenta Short Communication The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(−/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(−/−) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR. Elsevier 2016-06 /pmc/articles/PMC4898207/ /pubmed/27238710 http://dx.doi.org/10.1016/j.placenta.2016.04.003 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
Finn-Sell, Sarah L.
Renshall, Lewis J.
Cowley, Elizabeth J.
Dilworth, Mark R.
Wareing, Mark
Greenwood, Susan L.
Sibley, Colin P.
Cottrell, Elizabeth C.
The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title_full The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title_fullStr The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title_full_unstemmed The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title_short The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
title_sort atrial natriuretic peptide (anp) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898207/
https://www.ncbi.nlm.nih.gov/pubmed/27238710
http://dx.doi.org/10.1016/j.placenta.2016.04.003
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