Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of...

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Autores principales: Yamada, Shunsuke, Tokumoto, Masanori, Taniguchi, Masatomo, Kitada, Hidehisa, Tsuruya, Kazuhiko, Kitazono, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898338/
https://www.ncbi.nlm.nih.gov/pubmed/27293572
http://dx.doi.org/10.1093/ckj/sft061
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author Yamada, Shunsuke
Tokumoto, Masanori
Taniguchi, Masatomo
Kitada, Hidehisa
Tsuruya, Kazuhiko
Kitazono, Takanari
author_facet Yamada, Shunsuke
Tokumoto, Masanori
Taniguchi, Masatomo
Kitada, Hidehisa
Tsuruya, Kazuhiko
Kitazono, Takanari
author_sort Yamada, Shunsuke
collection PubMed
description A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.
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spelling pubmed-48983382016-06-10 Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio Yamada, Shunsuke Tokumoto, Masanori Taniguchi, Masatomo Kitada, Hidehisa Tsuruya, Kazuhiko Kitazono, Takanari Clin Kidney J Clinical Cases A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio. Oxford University Press 2013-08 /pmc/articles/PMC4898338/ /pubmed/27293572 http://dx.doi.org/10.1093/ckj/sft061 Text en © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Yamada, Shunsuke
Tokumoto, Masanori
Taniguchi, Masatomo
Kitada, Hidehisa
Tsuruya, Kazuhiko
Kitazono, Takanari
Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title_full Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title_fullStr Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title_full_unstemmed Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title_short Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio
title_sort decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole pth/intact pth ratio
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898338/
https://www.ncbi.nlm.nih.gov/pubmed/27293572
http://dx.doi.org/10.1093/ckj/sft061
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