Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome

We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of th...

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Detalles Bibliográficos
Autores principales: Langlois, Anne Lyse, Shehwaro, Nathalie, Rondet, Claire, Benbrik, Youssef, Maloum, Karim, Gueutin, Victor, Rouvier, Philippe, Izzedine, Hassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898340/
https://www.ncbi.nlm.nih.gov/pubmed/27293571
http://dx.doi.org/10.1093/ckj/sft067
Descripción
Sumario:We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.

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