Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome

We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of th...

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Autores principales: Langlois, Anne Lyse, Shehwaro, Nathalie, Rondet, Claire, Benbrik, Youssef, Maloum, Karim, Gueutin, Victor, Rouvier, Philippe, Izzedine, Hassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898340/
https://www.ncbi.nlm.nih.gov/pubmed/27293571
http://dx.doi.org/10.1093/ckj/sft067
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author Langlois, Anne Lyse
Shehwaro, Nathalie
Rondet, Claire
Benbrik, Youssef
Maloum, Karim
Gueutin, Victor
Rouvier, Philippe
Izzedine, Hassane
author_facet Langlois, Anne Lyse
Shehwaro, Nathalie
Rondet, Claire
Benbrik, Youssef
Maloum, Karim
Gueutin, Victor
Rouvier, Philippe
Izzedine, Hassane
author_sort Langlois, Anne Lyse
collection PubMed
description We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.
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spelling pubmed-48983402016-06-10 Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome Langlois, Anne Lyse Shehwaro, Nathalie Rondet, Claire Benbrik, Youssef Maloum, Karim Gueutin, Victor Rouvier, Philippe Izzedine, Hassane Clin Kidney J Original Contributions We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils. Oxford University Press 2013-08 /pmc/articles/PMC4898340/ /pubmed/27293571 http://dx.doi.org/10.1093/ckj/sft067 Text en © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contributions
Langlois, Anne Lyse
Shehwaro, Nathalie
Rondet, Claire
Benbrik, Youssef
Maloum, Karim
Gueutin, Victor
Rouvier, Philippe
Izzedine, Hassane
Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title_full Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title_fullStr Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title_full_unstemmed Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title_short Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome
title_sort renal thrombotic microangiopathy and fip1l1/pdgfrα-associated myeloproliferative variant of hypereosinophilic syndrome
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898340/
https://www.ncbi.nlm.nih.gov/pubmed/27293571
http://dx.doi.org/10.1093/ckj/sft067
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