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MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET
BACKGROUND/AIM: Increasing evidences show that microRNAs are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role of miR-502-3P in HCC and to identify its underlying mechanism. METHODS: The expression levels of miR-502-3P were assessed in multiple HCC cell lin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898420/ https://www.ncbi.nlm.nih.gov/pubmed/27330307 http://dx.doi.org/10.2147/OTT.S87183 |
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author | Jin, Haosheng Yu, Min Lin, Ye Hou, Baohua Wu, Zhongshi Li, Zhide Sun, Jian |
author_facet | Jin, Haosheng Yu, Min Lin, Ye Hou, Baohua Wu, Zhongshi Li, Zhide Sun, Jian |
author_sort | Jin, Haosheng |
collection | PubMed |
description | BACKGROUND/AIM: Increasing evidences show that microRNAs are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role of miR-502-3P in HCC and to identify its underlying mechanism. METHODS: The expression levels of miR-502-3P were assessed in multiple HCC cell lines and in liver tissues of patients with HCC. We further examined the effects of miR-502-3P on malignant behavior of HCC. The molecular target of miR-502-3P was identified using a computer algorithm and confirmed experimentally. RESULTS: Downregulation of miR-502-3P was found in both HCC cell lines and human samples. Overexpression of miR-502-3P dramatically inhibits HCC proliferation, metastasis, invasion, and cell adhesion. We further verify the SET as a novel and direct target of miR-502-3P in HCCs. CONCLUSION: Taken together, overexpression of miR-502-3P or downregulation of SET may prove beneficial as a therapeutic strategy for HCC treatment. |
format | Online Article Text |
id | pubmed-4898420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48984202016-06-21 MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET Jin, Haosheng Yu, Min Lin, Ye Hou, Baohua Wu, Zhongshi Li, Zhide Sun, Jian Onco Targets Ther Original Research BACKGROUND/AIM: Increasing evidences show that microRNAs are engaged in hepatocellular carcinoma (HCC). The aim of this study was to investigate the role of miR-502-3P in HCC and to identify its underlying mechanism. METHODS: The expression levels of miR-502-3P were assessed in multiple HCC cell lines and in liver tissues of patients with HCC. We further examined the effects of miR-502-3P on malignant behavior of HCC. The molecular target of miR-502-3P was identified using a computer algorithm and confirmed experimentally. RESULTS: Downregulation of miR-502-3P was found in both HCC cell lines and human samples. Overexpression of miR-502-3P dramatically inhibits HCC proliferation, metastasis, invasion, and cell adhesion. We further verify the SET as a novel and direct target of miR-502-3P in HCCs. CONCLUSION: Taken together, overexpression of miR-502-3P or downregulation of SET may prove beneficial as a therapeutic strategy for HCC treatment. Dove Medical Press 2016-05-31 /pmc/articles/PMC4898420/ /pubmed/27330307 http://dx.doi.org/10.2147/OTT.S87183 Text en © 2016 Jin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Jin, Haosheng Yu, Min Lin, Ye Hou, Baohua Wu, Zhongshi Li, Zhide Sun, Jian MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title | MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title_full | MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title_fullStr | MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title_full_unstemmed | MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title_short | MiR-502-3P suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SET |
title_sort | mir-502-3p suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting set |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898420/ https://www.ncbi.nlm.nih.gov/pubmed/27330307 http://dx.doi.org/10.2147/OTT.S87183 |
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