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Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging

The aim is to investigate the relationship between microstructural white matter (WM) diffusivity indices and macrostructural WM volume (WMV) among healthy individuals (20–85 years). Whole-brain diffusion measures were calculated from diffusion tensor imaging using FMRIB software library while WMV wa...

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Detalles Bibliográficos
Autores principales: Rathee, Rishu, Rallabandi, V.P. Subramanyam, Roy, Prasun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898444/
https://www.ncbi.nlm.nih.gov/pubmed/27279747
http://dx.doi.org/10.4137/MRI.S39666
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author Rathee, Rishu
Rallabandi, V.P. Subramanyam
Roy, Prasun K.
author_facet Rathee, Rishu
Rallabandi, V.P. Subramanyam
Roy, Prasun K.
author_sort Rathee, Rishu
collection PubMed
description The aim is to investigate the relationship between microstructural white matter (WM) diffusivity indices and macrostructural WM volume (WMV) among healthy individuals (20–85 years). Whole-brain diffusion measures were calculated from diffusion tensor imaging using FMRIB software library while WMV was estimated through voxel-based morphometry, and voxel-based analysis was carried out using tract-based spatial statistics. Our results revealed that mean diffusivity, axial diffusivity, and radial diffusivity had shown good correlation with WMV but not for fractional anisotropy (FA). Voxel-wise tract-based spatial statistics analysis for FA showed a significant decrease in four regions for middle-aged group compared to young-aged group, in 22 regions for old-aged group compared to middle-aged group, and in 26 regions for old-aged group compared to young-aged group (P < 0.05). We found significantly lower WMV, FA, and mean diffusivity values in females than males and inverted-U trend for FA in males. We conclude differential age- and gender-related changes for structural WMV and WM diffusion indices.
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spelling pubmed-48984442016-06-08 Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging Rathee, Rishu Rallabandi, V.P. Subramanyam Roy, Prasun K. Magn Reson Insights Original Research The aim is to investigate the relationship between microstructural white matter (WM) diffusivity indices and macrostructural WM volume (WMV) among healthy individuals (20–85 years). Whole-brain diffusion measures were calculated from diffusion tensor imaging using FMRIB software library while WMV was estimated through voxel-based morphometry, and voxel-based analysis was carried out using tract-based spatial statistics. Our results revealed that mean diffusivity, axial diffusivity, and radial diffusivity had shown good correlation with WMV but not for fractional anisotropy (FA). Voxel-wise tract-based spatial statistics analysis for FA showed a significant decrease in four regions for middle-aged group compared to young-aged group, in 22 regions for old-aged group compared to middle-aged group, and in 26 regions for old-aged group compared to young-aged group (P < 0.05). We found significantly lower WMV, FA, and mean diffusivity values in females than males and inverted-U trend for FA in males. We conclude differential age- and gender-related changes for structural WMV and WM diffusion indices. Libertas Academica 2016-06-07 /pmc/articles/PMC4898444/ /pubmed/27279747 http://dx.doi.org/10.4137/MRI.S39666 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Rathee, Rishu
Rallabandi, V.P. Subramanyam
Roy, Prasun K.
Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title_full Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title_fullStr Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title_full_unstemmed Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title_short Age-Related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural MRI and Diffusion Tensor Imaging
title_sort age-related differences in white matter integrity in healthy human brain: evidence from structural mri and diffusion tensor imaging
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898444/
https://www.ncbi.nlm.nih.gov/pubmed/27279747
http://dx.doi.org/10.4137/MRI.S39666
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